%0 Journal Article %1 Monset-Couchard1992 %A Monset-Couchard, M. %A de Bethmann, O. %A Kastler, B. %A Relier, J. P. %D 1992 %J Pediatrie %K Cerebral Palsy; Child Development; Child, Preschool; Female; Follow-Up Studies; Humans; Infant, Newborn; Leukomalacia, Periventricular; Male; Treatment Outcome %N 5 %P 391--397 %T Mid-term and long-term outcome in newborn infants with periventricular leukomalacia (53 cases) %V 47 %X During the period 1983-1987, 53 neonates (30 boys, 23 girls, mean birth weight 1,438 +/- 317 g, mean gestational age 30 +/- 2 weeks) were found to have cystic periventricular leukomalacias (CPVL) detected by brain ultrasonography. The neuro-developmental follow-up was 3-7 years. Seventeen CPVL were isolated and CPVL were associated with minor peri-intraventricular hemorrhage (0-1 to II-II) in 36 cases. CPVL included 16 minor forms (11 normal children; 2 minor, 3 moderate sequelae), 29 moderate forms (15 normal children; 4 minor, 7 moderate, 3 major sequelae) and 8 major forms (7 major sequelae, one moderate mental retardation without motor deficit). According to reverse analysis, a normal evolution (26 cases) followed CPVL which were sometimes widely, but thinly spread over the ventricles (thickness 1/5-1/3 of the cerebral mantle); minor sequelae (6 cases) were associated with a 1/4-1/3 thickness, moderate sequelae (11 cases) with a 1/3-1/2 thickness, major sequelae (10 cases) with a 1/2-2/3 thickness of CPVL. The thickness of the lesions appeared to be more predictive of sequelae than the sagittal extent, in particular that of the posterior CPVL which played a major role in the severity of sequelae, and mainly in the presence of motor deficits.

@article{Monset-Couchard1992, abstract = {During the period 1983-1987, 53 neonates (30 boys, 23 girls, mean birth weight 1,438 +/- 317 g, mean gestational age 30 +/- 2 weeks) were found to have cystic periventricular leukomalacias (CPVL) detected by brain ultrasonography. The neuro-developmental follow-up was 3-7 years. Seventeen CPVL were isolated and CPVL were associated with minor peri-intraventricular hemorrhage (0-1 to II-II) in 36 cases. CPVL included 16 minor forms (11 normal children; 2 minor, 3 moderate sequelae), 29 moderate forms (15 normal children; 4 minor, 7 moderate, 3 major sequelae) and 8 major forms (7 major sequelae, one moderate mental retardation without motor deficit). According to reverse analysis, a normal evolution (26 cases) followed CPVL which were sometimes widely, but thinly spread over the ventricles (thickness 1/5-1/3 of the cerebral mantle); minor sequelae (6 cases) were associated with a 1/4-1/3 thickness, moderate sequelae (11 cases) with a 1/3-1/2 thickness, major sequelae (10 cases) with a 1/2-2/3 thickness of CPVL. The thickness of the lesions appeared to be more predictive of sequelae than the sagittal extent, in particular that of the posterior CPVL which played a major role in the severity of sequelae, and mainly in the presence of motor deficits.}, added-at = {2014-07-19T20:48:39.000+0200}, author = {Monset-Couchard, M. and de Bethmann, O. and Kastler, B. and Relier, J. P.}, biburl = {https://www.bibsonomy.org/bibtex/2e735cc1857c868f315a69f9eb8f26174/ar0berts}, groups = {public}, interhash = {014878c3ecce91405b7bad65b955efb1}, intrahash = {e735cc1857c868f315a69f9eb8f26174}, journal = {Pediatrie}, keywords = {Cerebral Palsy; Child Development; Child, Preschool; Female; Follow-Up Studies; Humans; Infant, Newborn; Leukomalacia, Periventricular; Male; Treatment Outcome}, number = 5, pages = {391--397}, pmid = {1331955}, timestamp = {2014-07-19T20:48:39.000+0200}, title = {[Mid-term and long-term outcome in newborn infants with periventricular leukomalacia (53 cases)]}, username = {ar0berts}, volume = 47, year = 1992 }