%0 Journal Article %1 cox-mil %A Cox, G %A Miller, JD %A McWilliams, A %A FitzGerald, JM %A Lam, S %C 1740 BROADWAY, NEW YORK, NY 10019-4374 USA %D 2006 %I AMER THORACIC SOC %J AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE %K asthma thermoplasty %N 9 %P 965-969 %R 10.1164/rccm.200507-1162OC %T Bronchial thermoplasty for asthma %V 173 %X Rationale: Bronchial thermoplasty (BT) reduces the potential for smooth muscle-mediated bronchoconstriction by reducing the mass of smooth muscle in the walls of conducting airways. Objectives: This study was conducted to examine the safety and impact on lung function and airway responsiveness of BT over 2 yr. Methods: The safety of BT was studied in 16 subjects with mild to moderate asthma. Baseline and 12-wk post-treatment measurements included spirometry, methacholine challenge, daily diary recordings of peak flow, symptoms, and medication usage. Subjects completed follow-up evaluations at 12 wk, 1 yr, and 2 yr. Measurements and Main Results: The procedure was well tolerated; side effects were transient and typical of what is commonly observed after bronchoscopy. All subjects demonstrated improvement in airway responsiveness. The mean PC20 increased by 2.37 +/- 1.72 (p < 0.001), 2.77 +/- 1.53 (p = 0.007), and 2.64 +/- 1.52 doublings (p < 0.001), at 12 wk, 1 yr, and 2 yr post-procedure, respectively. Data from daily diaries collected for 12 wk indicated significant improvements over baseline in symptom-free days (p = 0.015), morning peak flow (p = 0.01), and evening peak flow (p = 0.007). Spirometry measurements remained stable throughout the study period. Conclusions: BT is well tolerated in patients with asthma and results in decreased airway hyperresponsiveness that persists for at least 2 yr.

@article{cox-mil, abstract = {{Rationale: Bronchial thermoplasty (BT) reduces the potential for smooth muscle-mediated bronchoconstriction by reducing the mass of smooth muscle in the walls of conducting airways. Objectives: This study was conducted to examine the safety and impact on lung function and airway responsiveness of BT over 2 yr. Methods: The safety of BT was studied in 16 subjects with mild to moderate asthma. Baseline and 12-wk post-treatment measurements included spirometry, methacholine challenge, daily diary recordings of peak flow, symptoms, and medication usage. Subjects completed follow-up evaluations at 12 wk, 1 yr, and 2 yr. Measurements and Main Results: The procedure was well tolerated; side effects were transient and typical of what is commonly observed after bronchoscopy. All subjects demonstrated improvement in airway responsiveness. The mean PC20 increased by 2.37 +/- 1.72 (p < 0.001), 2.77 +/- 1.53 (p = 0.007), and 2.64 +/- 1.52 doublings (p < 0.001), at 12 wk, 1 yr, and 2 yr post-procedure, respectively. Data from daily diaries collected for 12 wk indicated significant improvements over baseline in symptom-free days (p = 0.015), morning peak flow (p = 0.01), and evening peak flow (p = 0.007). Spirometry measurements remained stable throughout the study period. Conclusions: BT is well tolerated in patients with asthma and results in decreased airway hyperresponsiveness that persists for at least 2 yr.}}, added-at = {2013-01-07T12:38:19.000+0100}, address = {{1740 BROADWAY, NEW YORK, NY 10019-4374 USA}}, affiliation = {{Cox, G (Reprint Author), McMaster Univ, Firestone Inst Resp Hlth, St Josephs Healthcare, 50 Charlton Ave, Hamilton, ON L8N 4A6, Canada.. McMaster Univ, Firestone Inst Resp Hlth, St Josephs Healthcare, Hamilton, ON L8N 4A6, Canada. Univ British Columbia, Vancouver Gen Hosp, Vancouver, BC V5Z 1M9, Canada.}}, author = {Cox, G and Miller, JD and McWilliams, A and FitzGerald, JM and Lam, S}, author-email = {{coxp@mcmaster.ca}}, biburl = {https://www.bibsonomy.org/bibtex/2fbb23904c88e065f218f5429d4990752/jehiorns}, doc-delivery-number = {{039UI}}, doi = {{10.1164/rccm.200507-1162OC}}, interhash = {033e729b9a70aae63f9821209ef02e39}, intrahash = {fbb23904c88e065f218f5429d4990752}, issn = {{1073-449X}}, journal = {{AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE}}, journal-iso = {{Am. J. Respir. Crit. Care Med.}}, keywords = {asthma thermoplasty}, keywords-plus = {{AIRWAY HYPERRESPONSIVENESS; EXERCISE CHALLENGE; MODERATE ASTHMA; SMOOTH-MUSCLE; METHACHOLINE; BRONCHOSCOPY; BIOPSY}}, language = {{English}}, month = {{MAY 1}}, number = {{9}}, number-of-cited-references = {{26}}, pages = {{965-969}}, publisher = {{AMER THORACIC SOC}}, research-areas = {{General \& Internal Medicine; Respiratory System}}, times-cited = {{86}}, timestamp = {2013-01-07T12:38:19.000+0100}, title = {{Bronchial thermoplasty for asthma}}, type = {{Article}}, unique-id = {{ISI:000237332400007}}, volume = {{173}}, web-of-science-categories = {{Critical Care Medicine; Respiratory System}}, year = {{2006}} }