%0 Journal Article %1 noauthororeditor1984journal %A Luxenhofer, R. %A Sahay, G. %A Schulz, A. %A Alakhova, D. %A Bronich, T. K. %A Jordan, R. %A Kabanov, A. V. %C Amsterdam %D 2011 %I Elsevier Science Publishers %J Journal of controlled release %K rluxenhofer %N 1 %P 73-82 %T Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles %U http://www.sciencedirect.com/science/article/pii/S0168365911002252 %V 135 %X The family of poly(2-oxazoline)s (POx) is being increasingly investigated in the context of biomedical applications. We tested the relative cytotoxicity of POx and were able to confirm that these polymers are typically not cytotoxic even at high concentrations. Furthermore, we report structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini. The rate of endocytosis can be fine-tuned over a broad range by changing the polymer structure. The cellular uptake increases with the hydrophobic character of the polymers and is observed even at nanomolar concentrations. Considering the structural versatility of this class of polymers, the relative ease of preparation and their stability underlines the potential of POx as a promising platform candidate for the preparation of next-generation polymer therapeutics.

@article{noauthororeditor1984journal, abstract = {The family of poly(2-oxazoline)s (POx) is being increasingly investigated in the context of biomedical applications. We tested the relative cytotoxicity of POx and were able to confirm that these polymers are typically not cytotoxic even at high concentrations. Furthermore, we report structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini. The rate of endocytosis can be fine-tuned over a broad range by changing the polymer structure. The cellular uptake increases with the hydrophobic character of the polymers and is observed even at nanomolar concentrations. Considering the structural versatility of this class of polymers, the relative ease of preparation and their stability underlines the potential of POx as a promising platform candidate for the preparation of next-generation polymer therapeutics.}, added-at = {2012-11-28T12:56:22.000+0100}, address = {Amsterdam}, author = {Luxenhofer, R. and Sahay, G. and Schulz, A. and Alakhova, D. and Bronich, T. K. and Jordan, R. and Kabanov, A. V.}, biburl = {https://www.bibsonomy.org/bibtex/28c76dd15df4e780a70f31dd03484ad59/lctm}, interhash = {037e3594147894c46713c48e304013a3}, intrahash = {8c76dd15df4e780a70f31dd03484ad59}, issn = {01683659}, journal = {Journal of controlled release}, keywords = {rluxenhofer}, number = 1, pages = {73-82}, publisher = {Elsevier Science Publishers}, refid = {639061660}, timestamp = {2012-11-28T12:56:22.000+0100}, title = {Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles}, url = {http://www.sciencedirect.com/science/article/pii/S0168365911002252}, volume = 135, year = 2011 }