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On the dielectric behaviour of collagen-algal sulfated polysaccharide blends: Effect of glutaraldehyde crosslinking
BIOPHYSICAL CHEMISTRY, 120 (2): 154-159 (2006)
DOI: 10.1016/j.bpc.2005.11.001
Аннотация
In this paper, impedance measurements in the frequency range from 10(-2)
to 10(6) Hz are presented for collagen and algal sulfated polysaccharide
crosslinked films. We are considering the development of new
biomaterials which have potential applications in coating of
cardiovascular prostheses, support for cellular growth and in systems
for controlled drug delivery. The effect of crosslink sulfated
polysaccharide on the physical chemical properties of collagen was
studied using FT-infrared spectroscopy, differential scanning
calorimetry (DSC), dielectric spectroscopy. The resulting films
crosslinked with glutaraldehyde (GA) in concentrations of 0.001% and
0.05% when analysed by DSC, showed that the GA treatment not only left
the thermal stability of the collagen unaffected, but it also decreased
the thermal transition energy. Dielectric spectroscopy shows that the
effect of the crosslink on the blend film was associated to the decrease
and stabilization of the dielectric permittivity at low frequencies and
decreased its conductivity. (c) 2005 Elsevier B.V. All rights reserved.
