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Effect of Silver and Zinc Oxide Nanoparticles on Gene Expression of Some Swarming Genes in Proteus Mirabilis

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CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (2): 11-20 (марта 2023)

Аннотация

Background: Due to the emergence of multiple antibiotic resistance by P. mirabilis bacteria, it was necessary to search for alternatives other than antibiotics to eliminate these bacteria, and this is what prompted scientists to use nanoparticles, which are nano-size materials that have a significant impact on the components of the bacterial cell. Among these nanomaterials are zinc oxides, titanium oxides, copper, cobalt, silver and gold.Objectives: The study of effect of nanoparticles on the gene expression of some swarming genes in Proteus mirabilis bacteria.Methods: A total of 30 samples collected from urinary tract infections and wounds in sterile containers in different hospitals in Baquba city (Baquba Teaching Hospital and Al-Batool Hospital) were subjected to Molecular detection about wosA and rsbA genes and Detecting the effect of nanoparticles on gene expression of gene wosA and rsbA .

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