Article,

Computational insights into Caenorhabditis elegans vulval development

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Proceedings of the National Academy of Sciences of the United States of America, 102 (6): 1951--1956 (Feb 8, 2005)
DOI: 10.1073/pnas.0409433102

Abstract

Studies of Caenorhabditis elegans vulval development provide a paradigm for pattern formation during animal development. The fates of the six vulval precursor cells are specified by the combined action of an inductive signal that activates the EGF receptor mitogen-activated PK signaling pathway (specifying a primary fate) and a lateral signal mediated by LIN-12/Notch (specifying a secondary fate). Here we use methods devised for the engineering of complex reactive systems to model a biological system. We have chosen the visual formalism of statecharts and use it to formalize Sternberg and Horvitz's 1989 model Sternberg, P. W. & Horvitz, H…(more)

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