%0 Journal Article %1 undavillafuerte2024effectiveness %A Unda Villafuerte, Fabián %A Llobera Cànaves, Joan %A Estela Mantolan, Andreu %A Bassante Flores, Patricia %A Rigo Carratalà, Fernando %A Requena Hernández, Ana %A Oliver Oliver, Bartolomé %A Pou Bordoy, Joan %A Moreno Sancho, María Lucía %A Leiva, Alfonso %A Lorente Montalvo, Patricia %A Group, MEDICHY %C Switzerland %D 2024 %J Frontiers in cardiovascular medicine %K grapp-caib %P 1355037--1355037 %R 10.3389/fcvm.2024.1355037 %T Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial %U https://pubmed.ncbi.nlm.nih.gov/38836068 %V 11 %X BACKGROUND: Uncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting. METHODS: This study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline. RESULTS: A total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg ±14.8 vs. 142.7 mmHg ±15.0, adjusted mean difference: 8.7 mmHg 95% CI: 3.4, 13.9, p < 0.001) and a significantly lower diastolic blood pressure (83.5 mmHg ±8.8 vs. 87.00 mmHg ±9.0, adjusted mean difference: 5.4 95% CI: 2.9, 7.8, p < 0.0001). The intervention group also had significantly more patients who achieved successful blood pressure control (<140/90 mmHg; 54.4% vs. 32.9%, p = 0.011). DISCUSSION: Self-monitoring of blood pressure in combination with self-management of hypertensive medications, diet, and physical activity in a primary care setting leads to significantly lower blood pressure in patients with poorly controlled hypertension.Clinical Trial Registration: ClinicalTrials.gov, identifier ISRCTN14433778.

@article{undavillafuerte2024effectiveness, abstract = {BACKGROUND: Uncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting. METHODS: This study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline. RESULTS: A total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg [±14.8] vs. 142.7 mmHg [±15.0], adjusted mean difference: 8.7 mmHg [95% CI: 3.4, 13.9], p < 0.001) and a significantly lower diastolic blood pressure (83.5 mmHg [±8.8] vs. 87.00 mmHg [±9.0], adjusted mean difference: 5.4 [95% CI: 2.9, 7.8], p < 0.0001). The intervention group also had significantly more patients who achieved successful blood pressure control (<140/90 mmHg; 54.4% vs. 32.9%, p = 0.011). DISCUSSION: Self-monitoring of blood pressure in combination with self-management of hypertensive medications, diet, and physical activity in a primary care setting leads to significantly lower blood pressure in patients with poorly controlled hypertension.Clinical Trial Registration: ClinicalTrials.gov, identifier ISRCTN14433778.}, added-at = {2024-06-10T06:34:12.000+0200}, address = {Switzerland}, author = {Unda Villafuerte, Fabián and Llobera Cànaves, Joan and Estela Mantolan, Andreu and Bassante Flores, Patricia and Rigo Carratalà, Fernando and Requena Hernández, Ana and Oliver Oliver, Bartolomé and Pou Bordoy, Joan and Moreno Sancho, María Lucía and Leiva, Alfonso and Lorente Montalvo, Patricia and Group, MEDICHY}, biburl = {https://www.bibsonomy.org/bibtex/20b80f33306d7c1e680c44ed51681acf7/nachoricci}, comment = {38836068[pmid] PMC11148777[pmcid]}, description = {Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial - PubMed}, doi = {10.3389/fcvm.2024.1355037}, interhash = {a1ee0b388dc07c9764d01e66269b35a9}, intrahash = {0b80f33306d7c1e680c44ed51681acf7}, issn = {2297055X}, journal = {Frontiers in cardiovascular medicine}, keywords = {grapp-caib}, month = may, pages = {1355037--1355037}, timestamp = {2024-06-10T06:34:12.000+0200}, title = {Effectiveness of medication self-management, self-monitoring and a lifestyle intervention on hypertension in poorly controlled patients: The MEDICHY randomized trial}, url = {https://pubmed.ncbi.nlm.nih.gov/38836068}, volume = 11, year = 2024 }