Article,

The L-type calcium channel in the heart: the beat goes on.

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J. Clin. Invest., 115 (12): 3306--3317 (December 2005)
DOI: 10.1172/JCI27167

Abstract

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca$^2+$. Fascination with the role of Ca$^2+$ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca$^2+$ and the L-type voltage-dependent Ca$^2+$ channels in cardiac disease.

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