Abstract
Sydney Ringer would be overwhelmed today by the implications of his
simple experiment performed over 120 years ago showing that the heart
would not beat in the absence of Ca$^2+$. Fascination with the
role of Ca$^2+$ has proliferated into all aspects of our understanding
of normal cardiac function and the progression of heart disease,
including induction of cardiac hypertrophy, heart failure, and sudden
death. This review examines the role of Ca$^2+$ and the L-type
voltage-dependent Ca$^2+$ channels in cardiac disease.
- 16322774
- acid
- amino
- animals,
- atrial
- biological,
- calcium
- calcium,
- calmodulin,
- cardiac,
- channels,
- congestive,
- distribution,
- extramural,
- failure,
- fibrillation,
- heart
- humans,
- isoforms,
- l-type,
- models,
- motifs,
- myocytes,
- n.i.h.,
- protein
- research
- structure,
- support,
- tertiary,
- tissue
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