%0 Journal Article %1 Franzosa2012Toward %A Franzosa, Eric A. %A Garamszegi, Sara %A Xia, Yu %D 2012 %J Frontiers in microbiology %K protein-protein-interactions protein-structures %R 10.3389/fmicb.2012.00428 %T Toward a three-dimensional view of protein networks between species. %U http://dx.doi.org/10.3389/fmicb.2012.00428 %V 3 %X General principles governing biomolecular interactions between species are expected to differ significantly from known principles governing the interactions within species, yet these principles remain poorly understood at the systems level. A key reason for this knowledge gap is the lack of a detailed three-dimensional (3D), atomistic view of biomolecular interaction networks between species. Recent progress in structural biology, systems biology, and computational biology has enabled accurate and large-scale construction of 3D structural models of nodes and edges for protein-protein interaction networks within and between species. The resulting within- and between-species structural interaction networks have provided new biophysical, functional, and evolutionary insights into species interactions and infectious disease. Here, we review the nascent field of between-species structural systems biology, focusing on interactions between host and pathogens such as viruses.

@article{Franzosa2012Toward, abstract = { General principles governing biomolecular interactions between species are expected to differ significantly from known principles governing the interactions within species, yet these principles remain poorly understood at the systems level. A key reason for this knowledge gap is the lack of a detailed three-dimensional ({3D}), atomistic view of biomolecular interaction networks between species. Recent progress in structural biology, systems biology, and computational biology has enabled accurate and large-scale construction of {3D} structural models of nodes and edges for protein-protein interaction networks within and between species. The resulting within- and between-species structural interaction networks have provided new biophysical, functional, and evolutionary insights into species interactions and infectious disease. Here, we review the nascent field of between-species structural systems biology, focusing on interactions between host and pathogens such as viruses. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Franzosa, Eric A. and Garamszegi, Sara and Xia, Yu}, biburl = {https://www.bibsonomy.org/bibtex/2be232588d7dab7708dec987585da1e06/karthikraman}, citeulike-article-id = {12205740}, citeulike-linkout-0 = {http://dx.doi.org/10.3389/fmicb.2012.00428}, citeulike-linkout-1 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528071/}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/23267356}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=23267356}, doi = {10.3389/fmicb.2012.00428}, interhash = {05d0d5890ee429ba638e3d454ddbd191}, intrahash = {be232588d7dab7708dec987585da1e06}, issn = {1664-302X}, journal = {Frontiers in microbiology}, keywords = {protein-protein-interactions protein-structures}, pmcid = {PMC3528071}, pmid = {23267356}, posted-at = {2013-03-25 06:12:04}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Toward a three-dimensional view of protein networks between species.}, url = {http://dx.doi.org/10.3389/fmicb.2012.00428}, volume = 3, year = 2012 }