%0 Journal Article %1 navon-venezia_plasmid-mediated_2006 %A Navon-Venezia, Shiri %A Chmelnitsky, Inna %A Leavitt, Azita %A Schwaber, Mitchell J. %A Schwartz, David %A Carmeli, Yehuda %D 2006 %J Antimicrob. Agents Chemother. %K imported %N 9 %P 3098--3101 %R 10.1128/AAC.00438-06 %T Plasmid-Mediated Imipenem-Hydrolyzing Enzyme KPC-2 among Multiple Carbapenem-Resistant Escherichia coli Clones in Israel %U http://aac.asm.org/cgi/content/abstract/50/9/3098 %V 50 %X Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. PCR, sequencing, and Southern blot analysis identified KPC-2 as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States.

@article{navon-venezia_plasmid-mediated_2006, abstract = {Carbapenem resistance in Escherichia coli is rare. We report four genetically unrelated carbapenem-resistant E. coli isolates cultured from four patients hospitalized in Tel Aviv Medical Center. {PCR,} sequencing, and Southern blot analysis identified {KPC-2} as the imipenem-hydrolyzing enzyme in all four strains, carried on different plasmids with a possible common origin. This is the first discovery of {KPC-2} in E. coli and the first report of this enzyme originating outside the United States.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {{Navon-Venezia}, Shiri and Chmelnitsky, Inna and Leavitt, Azita and Schwaber, Mitchell J. and Schwartz, David and Carmeli, Yehuda}, biburl = {https://www.bibsonomy.org/bibtex/20a084220f511984009a7dcbe6b115fd2/jelias}, doi = {10.1128/AAC.00438-06}, interhash = {0d4430ee6bdd77b48ded269f3592354b}, intrahash = {0a084220f511984009a7dcbe6b115fd2}, journal = {Antimicrob. Agents Chemother.}, keywords = {imported}, month = sep, number = 9, pages = {3098--3101}, timestamp = {2011-03-11T10:06:12.000+0100}, title = {{Plasmid-Mediated} {Imipenem-Hydrolyzing} Enzyme {KPC-2} among Multiple {Carbapenem-Resistant} Escherichia coli Clones in Israel}, url = {http://aac.asm.org/cgi/content/abstract/50/9/3098}, volume = 50, year = 2006 }