%0 Journal Article %1 Mukhtar2011Independently %A Mukhtar, M. Shahid %A Carvunis, Anne-Ruxandra %A Dreze, Matija %A Epple, Petra %A Steinbrenner, Jens %A Moore, Jonathan %A Tasan, Murat %A Galli, Mary %A Hao, Tong %A Nishimura, Marc T. %A Pevzner, Samuel J. %A Donovan, Susan E. %A Ghamsari, Lila %A Santhanam, Balaji %A Romero, Viviana %A Poulin, Matthew M. %A Gebreab, Fana %A Gutierrez, Bryan J. %A Tam, Stanley %A Monachello, Dario %A Boxem, Mike %A Harbort, Christopher J. %A McDonald, Nathan %A Gai, Lantian %A Chen, Huaming %A He, Yijian %A Consortium, European Union Effectoromics %A Vandenhaute, Jean %A Roth, Frederick P. %A Hill, David E. %A Ecker, Joseph R. %A Vidal, Marc %A Beynon, Jim %A Braun, Pascal %A Dangl, Jeffery L. %D 2011 %J Science %K immunology interaction-networks plants %N 6042 %P 596--601 %R 10.1126/science.1203659 %T Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network %U http://dx.doi.org/10.1126/science.1203659 %V 333 %X Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and \~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.

@article{Mukhtar2011Independently, abstract = {Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and \~{}8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Mukhtar, M. Shahid and Carvunis, Anne-Ruxandra and Dreze, Matija and Epple, Petra and Steinbrenner, Jens and Moore, Jonathan and Tasan, Murat and Galli, Mary and Hao, Tong and Nishimura, Marc T. and Pevzner, Samuel J. and Donovan, Susan E. and Ghamsari, Lila and Santhanam, Balaji and Romero, Viviana and Poulin, Matthew M. and Gebreab, Fana and Gutierrez, Bryan J. and Tam, Stanley and Monachello, Dario and Boxem, Mike and Harbort, Christopher J. and McDonald, Nathan and Gai, Lantian and Chen, Huaming and He, Yijian and Consortium, European Union Effectoromics and Vandenhaute, Jean and Roth, Frederick P. and Hill, David E. and Ecker, Joseph R. and Vidal, Marc and Beynon, Jim and Braun, Pascal and Dangl, Jeffery L.}, biburl = {https://www.bibsonomy.org/bibtex/2627ecf939181ddbe72d601e3f4da7421/karthikraman}, citeulike-article-id = {9594098}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1203659}, citeulike-linkout-1 = {http://www.sciencemag.org/content/333/6042/596.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/333/6042/596.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/333/6042/596}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/21798943}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=21798943}, day = 29, doi = {10.1126/science.1203659}, interhash = {0f759ce0242e96e87dd5753f183b7046}, intrahash = {627ecf939181ddbe72d601e3f4da7421}, journal = {Science}, keywords = {immunology interaction-networks plants}, month = jul, number = 6042, pages = {596--601}, pmid = {21798943}, posted-at = {2011-07-29 08:08:20}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network}, url = {http://dx.doi.org/10.1126/science.1203659}, volume = 333, year = 2011 }