%0 Journal Article %1 Lawson2005 %A Lawson, Sibi R %A Gabra, Bichoy H %A Guérin, Brigitte %A Neugebauer, Witold %A Nantel, François %A Battistini, Bruno %A Sirois, Pierre %D 2005 %J Regul Pept %K drugeffects;DiabetesMellitus chemicallyinduced/metabolism;Male;Rats;Rats bloodsupply/drugeffects;Streptozocin Type1 antagonists/&/inhibitors/metabolism;Retina BradykininB1 Animals;CapillaryPermeability Wistar;Receptor pharmacology drugeffects;Skin %N 1-3 %P 221--224 %R 10.1016/j.regpep.2004.09.002 %T Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist. %U http://dx.doi.org/10.1016/j.regpep.2004.09.002 %V 124 %X The vascular complications associated with type 1 diabetes are to some extent related to the dysfunction of the endothelium leading to an increased vascular permeability and plasma extravasation in the surrounding tissues. The various micro- and macro-vascular complications of diabetes develop over time, leading to nephropathy, retinopathy and neuropathy and cardiomyopathy. In the present study, the effect of a novel selective bradykinin B1 receptor (BKB1-R) antagonist, R-954, was investigated on the changes of vascular permeability in the skin and retina of streptozotocin (STZ)-induced type 1 diabetic rats. Plasma extravasation increased in the skin and retina of STZ-diabetic rats after 1 week and persisted over 4 weeks following STZ injection. Acute treatment with R-954 (2 mg/kg, bolus s.c.) highly reduced the elevated vascular permeability in both 1- and 4-week STZ-diabetic rats. These results showed that the inducible BKB1-R subtype modulates the vascular permeability of the skin and retina of type 1 diabetic rats and suggests that BKB1-R antagonists could have a beneficial role in diabetic neuropathy and retinopathy.

@article{Lawson2005, abstract = {The vascular complications associated with type 1 diabetes are to some extent related to the dysfunction of the endothelium leading to an increased vascular permeability and plasma extravasation in the surrounding tissues. The various micro- and macro-vascular complications of diabetes develop over time, leading to nephropathy, retinopathy and neuropathy and cardiomyopathy. In the present study, the effect of a novel selective bradykinin B1 receptor (BKB1-R) antagonist, R-954, was investigated on the changes of vascular permeability in the skin and retina of streptozotocin (STZ)-induced type 1 diabetic rats. Plasma extravasation increased in the skin and retina of STZ-diabetic rats after 1 week and persisted over 4 weeks following STZ injection. Acute treatment with R-954 (2 mg/kg, bolus s.c.) highly reduced the elevated vascular permeability in both 1- and 4-week STZ-diabetic rats. These results showed that the inducible BKB1-R subtype modulates the vascular permeability of the skin and retina of type 1 diabetic rats and suggests that BKB1-R antagonists could have a beneficial role in diabetic neuropathy and retinopathy.}, added-at = {2011-08-01T20:07:51.000+0200}, author = {Lawson, Sibi R and Gabra, Bichoy H and Guérin, Brigitte and Neugebauer, Witold and Nantel, François and Battistini, Bruno and Sirois, Pierre}, biburl = {https://www.bibsonomy.org/bibtex/2210ba6593244184adc4e11098efe7e8c/crc_chus}, doi = {10.1016/j.regpep.2004.09.002}, institution = {Institute of Pharmacology of Sherbrooke, School of Medicine, University of Sherbrooke, Sherbrooke, PQ, J1H 5N4, Canada.}, interhash = {1c479bacb288a26a529261752eed323b}, intrahash = {210ba6593244184adc4e11098efe7e8c}, journal = {Regul Pept}, keywords = {drugeffects;DiabetesMellitus chemicallyinduced/metabolism;Male;Rats;Rats bloodsupply/drugeffects;Streptozocin Type1 antagonists/&/inhibitors/metabolism;Retina BradykininB1 Animals;CapillaryPermeability Wistar;Receptor pharmacology drugeffects;Skin}, language = {eng}, medline-pst = {ppublish}, month = Jan, number = {1-3}, pages = {221--224}, pii = {S0167-0115(04)00351-9}, pmid = {15544863}, timestamp = {2011-08-01T20:07:51.000+0200}, title = {Enhanced dermal and retinal vascular permeability in streptozotocin-induced type 1 diabetes in Wistar rats: blockade with a selective bradykinin B1 receptor antagonist.}, url = {http://dx.doi.org/10.1016/j.regpep.2004.09.002}, volume = 124, year = 2005 }