%0 Journal Article %1 Wang2010Acetylation %A Wang, Qijun %A Zhang, Yakun %A Yang, Chen %A Xiong, Hui %A Lin, Yan %A Yao, Jun %A Li, Hong %A Xie, Lu %A Zhao, Wei %A Yao, Yufeng %A Ning, Zhi-Bin B. %A Zeng, Rong %A Xiong, Yue %A Guan, Kun-Liang L. %A Zhao, Shimin %A Zhao, Guo-Ping P. %D 2010 %J Science (New York, N.Y.) %K acetylation flux-analysis metabolism %N 5968 %P 1004--1007 %R 10.1126/science.1179687 %T Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. %U http://dx.doi.org/10.1126/science.1179687 %V 327 %X Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown. We demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux. The relative activities of key enzymes controlling the direction of glycolysis versus gluconeogenesis and the branching between citrate cycle and glyoxylate bypass were all regulated by acetylation. This modulation is mainly controlled by a pair of lysine acetyltransferase and deacetylase, whose expressions are coordinated with growth status. Reversible acetylation of metabolic enzymes ensure that cells respond environmental changes via promptly sensing cellular energy status and flexibly altering reaction rates or directions. It represents a metabolic regulatory mechanism conserved from bacteria to mammals.

@article{Wang2010Acetylation, abstract = { Lysine acetylation regulates many eukaryotic cellular processes, but its function in prokaryotes is largely unknown. We demonstrated that central metabolism enzymes in Salmonella were acetylated extensively and differentially in response to different carbon sources, concomitantly with changes in cell growth and metabolic flux. The relative activities of key enzymes controlling the direction of glycolysis versus gluconeogenesis and the branching between citrate cycle and glyoxylate bypass were all regulated by acetylation. This modulation is mainly controlled by a pair of lysine acetyltransferase and deacetylase, whose expressions are coordinated with growth status. Reversible acetylation of metabolic enzymes ensure that cells respond environmental changes via promptly sensing cellular energy status and flexibly altering reaction rates or directions. It represents a metabolic regulatory mechanism conserved from bacteria to mammals. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Wang, Qijun and Zhang, Yakun and Yang, Chen and Xiong, Hui and Lin, Yan and Yao, Jun and Li, Hong and Xie, Lu and Zhao, Wei and Yao, Yufeng and Ning, Zhi-Bin B. and Zeng, Rong and Xiong, Yue and Guan, Kun-Liang L. and Zhao, Shimin and Zhao, Guo-Ping P.}, biburl = {https://www.bibsonomy.org/bibtex/2515fde13876ed7e0cb7cae64b5ba4a52/karthikraman}, citeulike-article-id = {6700873}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1179687}, citeulike-linkout-1 = {http://www.sciencemag.org/content/327/5968/1004.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/327/5968/1004.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/327/5968/1004}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/20167787}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=20167787}, day = 19, doi = {10.1126/science.1179687}, interhash = {33825413e78aef652191c26a58d5ee68}, intrahash = {515fde13876ed7e0cb7cae64b5ba4a52}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {acetylation flux-analysis metabolism}, month = feb, number = 5968, pages = {1004--1007}, pmid = {20167787}, posted-at = {2010-02-19 11:31:44}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.}, url = {http://dx.doi.org/10.1126/science.1179687}, volume = 327, year = 2010 }