%0 Journal Article %1 EriNobusawa04012006 %A Nobusawa, Eri %A Sato, Katsuhiko %D 2006 %J J. Virol. %K data imported influenza mutation %N 7 %P 3675-3678 %R 10.1128/JVI.80.7.3675-3678.2006 %T Comparison of the Mutation Rates of Human Influenza A and B Viruses %U http://jvi.asm.org/cgi/content/abstract/80/7/3675 %V 80 %X Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 x 10-6 and 0.6 x 10-6 mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates.

@article{EriNobusawa04012006, abstract = {Human influenza A viruses evolve more rapidly than influenza B viruses. To clarify the cause of this difference, we have evaluated the mutation rate of the nonstructural gene as revealed by the genetic diversity observed during the growth of individual plaques in MDCK cells. Six plaques were studied, representing two strains each of type A and B viruses. A total of 813,663 nucleotides were sequenced, giving rates of 2.0 x 10-6 and 0.6 x 10-6 mutations per site per infectious cycle, which, when extended to 1 year, agree well with the published annual evolutionary rates. }, added-at = {2009-10-23T03:53:19.000+0200}, author = {Nobusawa, Eri and Sato, Katsuhiko}, biburl = {https://www.bibsonomy.org/bibtex/26185d47eea39573985c2191b73ee822b/ebo}, description = {Comparison of the Mutation Rates of Human Influenza A and B Viruses -- Nobusawa and Sato 80 (7): 3675 -- The Journal of Virology}, doi = {10.1128/JVI.80.7.3675-3678.2006}, eprint = {http://jvi.asm.org/cgi/reprint/80/7/3675.pdf}, interhash = {36675876b196b8612fc1362e4ab6d77e}, intrahash = {6185d47eea39573985c2191b73ee822b}, journal = {J. Virol.}, keywords = {data imported influenza mutation}, number = 7, pages = {3675-3678}, timestamp = {2009-10-23T03:53:19.000+0200}, title = {{Comparison of the Mutation Rates of Human Influenza A and B Viruses}}, url = {http://jvi.asm.org/cgi/content/abstract/80/7/3675}, volume = 80, year = 2006 }