Artikel,
A simplified model of airway narrowing due to bronchial mucosal folding
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 171 (2): 144-150 (April 2010)
DOI: {10.1016/j.resp.2010.02.011}
Zusammenfassung
Bronchial mucosal folding during bronchoconstriction can be a
significant phenomenon, and a number of previous studies have provided
models which examine a number of aspects of this Important problem
Previous approaches include finite-element analyses, fluid-structure
interaction, linear elasticity models, geometrical computer
optimisation, and more. These models have focused on changes to the
elastic properties of the airways due to mucosal folding, rather than
airway narrowing, and suffer from too great a degree of computational
complexity for use in multiscale, spatially distributed models of the
lung now being developed We propose a simplified, geometrical model of
airway folding under the assumptions of fixed airway wall area, fixed
basement membrane perimeter during constriction, specified shape and
number of folds, and liquid filling of the mucosal folds, in the context
of determining effective airway radius and hence airway impedance We
show that this model generates predictions in good agreement with
existing models while being vastly simpler to solve. (C) 2010 Elsevier B
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