Abstract
While progress has been made in determining the molecular basis for
the circadian clock, the mechanism by which mammalian brains time
intervals measured in seconds to minutes remains a mystery. An obvious
question is whether the interval-timing mechanism shares molecular
machinery with the circadian timing mechanism. In the current study,
we trained circadian CLOCK +/− and −/− mutant male mice in a peak-interval
procedure with 10 and 20-s criteria. The mutant mice were more active
than their wild-type littermates, but there were no reliable deficits
in the accuracy or precision of their timing as compared with wild-type
littermates. This suggests that expression of the CLOCK protein is
not necessary for normal interval timing.
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