%0 Journal Article %1 Genuis:2010:Sci-Total-Environ:20920818 %A Genuis, S J %D 2010 %J Sci Total Environ %K CSS Genuis TILT allergies allergy antibodies autoimmune_disease central_sensitivity_syndromes central_sensitization cytokines detoxification food_intolerances inflammation naltrexone sensitivity sensitivity-related_illness toxicology %N 24 %P 6047-6061 %R 10.1016/j.scitotenv.2010.08.047 %T Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity %U https://www.ncbi.nlm.nih.gov/pubmed/20920818 %V 408 %X The prevalence of allergic-related diseases, food intolerance, and chemical sensitivities in both the pediatric and adult population has increased dramatically over the last two decades, with escalating rates of associated morbidity. Conditions of acquired allergy, food intolerance and chemical hypersensitivity are frequently the direct sequelae of a toxicant induced loss of tolerance (TILT) in response to a significant initiating toxic exposure. Following the primary toxicant insult, the individuals become sensitive to low levels of diverse and unrelated triggers in their environment such as commonly encountered chemical, inhalant or food antigens. Among sensitized individuals, exposure to assorted inciting stimuli may precipitate diverse clinical and/or immune sequelae as may be evidenced by clinical symptoms as well as varied lymphocyte, antibody, or cytokine responses in some cases. Recently recognized as a mechanism of disease development, TILT and resultant sensitivity-related illness (SRI) may involve various organ systems and evoke wide-ranging physical or neuropsychological manifestations. With escalating rates of toxicant exposure and bioaccumulation in the population-at-large, an increasing proportion of contemporary illness is the direct result of TILT and ensuing SRI. Avoidance of triggers will preclude symptoms, and desensitization immunotherapy or immune suppression may ameliorate symptomatology in some cases. Resolution of SRI generally occurs on a gradual basis following the elimination of bioaccumulated toxicity and avoidance of further initiating adverse environmental exposures. As has usually been the case throughout medical history whenever new evidence regarding disease mechanisms emerges, resistance to the translation of knowledge abounds.

@article{Genuis:2010:Sci-Total-Environ:20920818, abstract = {The prevalence of allergic-related diseases, food intolerance, and chemical sensitivities in both the pediatric and adult population has increased dramatically over the last two decades, with escalating rates of associated morbidity. Conditions of acquired allergy, food intolerance and chemical hypersensitivity are frequently the direct sequelae of a toxicant induced loss of tolerance (TILT) in response to a significant initiating toxic exposure. Following the primary toxicant insult, the individuals become sensitive to low levels of diverse and unrelated triggers in their environment such as commonly encountered chemical, inhalant or food antigens. Among sensitized individuals, exposure to assorted inciting stimuli may precipitate diverse clinical and/or immune sequelae as may be evidenced by clinical symptoms as well as varied lymphocyte, antibody, or cytokine responses in some cases. Recently recognized as a mechanism of disease development, TILT and resultant sensitivity-related illness (SRI) may involve various organ systems and evoke wide-ranging physical or neuropsychological manifestations. With escalating rates of toxicant exposure and bioaccumulation in the population-at-large, an increasing proportion of contemporary illness is the direct result of TILT and ensuing SRI. Avoidance of triggers will preclude symptoms, and desensitization immunotherapy or immune suppression may ameliorate symptomatology in some cases. Resolution of SRI generally occurs on a gradual basis following the elimination of bioaccumulated toxicity and avoidance of further initiating adverse environmental exposures. As has usually been the case throughout medical history whenever new evidence regarding disease mechanisms emerges, resistance to the translation of knowledge abounds.}, added-at = {2019-05-22T16:32:58.000+0200}, author = {Genuis, S J}, biburl = {https://www.bibsonomy.org/bibtex/286b1d6f610db9a4dec386b51ff10ffee/eirc}, description = {FOR FULL PAPER SEE PDF ON THE RIGHT OF THIS PAGE! This is one of the most helpful articles on environmental intolerance I have read. Stephen Genuis ties together the various conditions experienced in environmental illness (he uses the term 'sensitivity-related illness'), including hyper-allergenicity, mold sensitivity, chemical sensitivity and electrical sensitivity. Each of these components, he suggests, are the result of toxicant induced loss of tolerance — perhaps even the result of one single initiating toxic exposure, or set of exposures. And as you can see from the title, he refers to this class of disease as a rising global pandemic. I've encountered many who believe that MCS (and the resulting mast cell activation) are genetically predetermined, but the evidence suggests this is not true. Though genes, of course, can set the table nicely, the research indicates that the condition is toxicant-induced, whether chemical, electrical or biological -- i.e., mold, bacterial. This is good news. It means that these conditions are, at least in theory, treatable. There are ways to get better. And this is much easier to do so if one knows what is going on. I hope this page can be a resource in which we can help each other paint a clearer picture of that, so we have more power to do something about it.}, doi = {10.1016/j.scitotenv.2010.08.047}, interhash = {5e5ce7aeb030fc96b9be932d768c0564}, intrahash = {86b1d6f610db9a4dec386b51ff10ffee}, journal = {Sci Total Environ}, keywords = {CSS Genuis TILT allergies allergy antibodies autoimmune_disease central_sensitivity_syndromes central_sensitization cytokines detoxification food_intolerances inflammation naltrexone sensitivity sensitivity-related_illness toxicology}, month = nov, number = 24, pages = {6047-6061}, pmid = {20920818}, timestamp = {2019-06-19T23:15:50.000+0200}, title = {Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity}, url = {https://www.ncbi.nlm.nih.gov/pubmed/20920818}, volume = 408, year = 2010 }