%0 Journal Article %1 Akiva2015Evolutionary %A Akiva, Eyal %A Babbitt, Patricia C. %D 2015 %I Elsevier %J Cell %K protein-protein-interactions %N 3 %P 535--537 %R 10.1016/j.cell.2015.10.010 %T Evolutionary Reprograming of Protein-Protein Interaction Specificity %U http://dx.doi.org/10.1016/j.cell.2015.10.010 %V 163 %X Using mutation libraries and deep sequencing, Aakre et al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results indicate probable trajectories via ?intermediate? proteins that are promiscuous, thus avoiding transitions via non-interactions. These results extend observations about other biological interactions and enzyme evolution, suggesting broadly general principles.

@article{Akiva2015Evolutionary, abstract = {Using mutation libraries and deep sequencing, Aakre et al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results indicate probable trajectories via ?intermediate? proteins that are promiscuous, thus avoiding transitions via non-interactions. These results extend observations about other biological interactions and enzyme evolution, suggesting broadly general principles.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Akiva, Eyal and Babbitt, Patricia C.}, biburl = {https://www.bibsonomy.org/bibtex/29a2b067128a46217729a4888e44a48ee/karthikraman}, citeulike-article-id = {13814288}, citeulike-linkout-0 = {http://www.cell.com/cell/abstract/S0092-8674(15)01323-9}, citeulike-linkout-1 = {http://dx.doi.org/10.1016/j.cell.2015.10.010}, day = 10, doi = {10.1016/j.cell.2015.10.010}, interhash = {6266524f95c3e90885e38c2e62c453a0}, intrahash = {9a2b067128a46217729a4888e44a48ee}, issn = {00928674}, journal = {Cell}, keywords = {protein-protein-interactions}, month = nov, number = 3, pages = {535--537}, posted-at = {2015-11-10 09:57:25}, priority = {2}, publisher = {Elsevier}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Evolutionary Reprograming of {Protein-Protein} Interaction Specificity}, url = {http://dx.doi.org/10.1016/j.cell.2015.10.010}, volume = 163, year = 2015 }