%0 Journal Article %1 Franzosa2015Sequencing %A Franzosa, Eric A. %A Hsu, Tiffany %A Sirota-Madi, Alexandra %A Shafquat, Afrah %A Abu-Ali, Galeb %A Morgan, Xochitl C. %A Huttenhower, Curtis %D 2015 %J Nature reviews. Microbiology %K communities microbiome %N 6 %P 360--372 %T Sequencing and beyond: integrating molecular 'omics' for microbial community profiling. %U http://view.ncbi.nlm.nih.gov/pubmed/25915636 %V 13 %X High-throughput DNA sequencing has proven invaluable for investigating diverse environmental and host-associated microbial communities. In this Review, we discuss emerging strategies for microbial community analysis that complement and expand traditional metagenomic profiling. These include novel DNA sequencing strategies for identifying strain-level microbial variation and community temporal dynamics; measuring multiple 'omic' data types that better capture community functional activity, such as transcriptomics, proteomics and metabolomics; and combining multiple forms of omic data in an integrated framework. We highlight studies in which the 'multi-omics' approach has led to improved mechanistic models of microbial community structure and function.

@article{Franzosa2015Sequencing, abstract = {High-throughput {DNA} sequencing has proven invaluable for investigating diverse environmental and host-associated microbial communities. In this Review, we discuss emerging strategies for microbial community analysis that complement and expand traditional metagenomic profiling. These include novel {DNA} sequencing strategies for identifying strain-level microbial variation and community temporal dynamics; measuring multiple 'omic' data types that better capture community functional activity, such as transcriptomics, proteomics and metabolomics; and combining multiple forms of omic data in an integrated framework. We highlight studies in which the 'multi-omics' approach has led to improved mechanistic models of microbial community structure and function.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Franzosa, Eric A. and Hsu, Tiffany and Sirota-Madi, Alexandra and Shafquat, Afrah and Abu-Ali, Galeb and Morgan, Xochitl C. and Huttenhower, Curtis}, biburl = {https://www.bibsonomy.org/bibtex/2a9e382b62d83bc0d4aff70438b4cf290/karthikraman}, citeulike-article-id = {13822880}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/25915636}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=25915636}, interhash = {6f432a7be2d7e6494b0568ff661d3101}, intrahash = {a9e382b62d83bc0d4aff70438b4cf290}, issn = {1740-1534}, journal = {Nature reviews. Microbiology}, keywords = {communities microbiome}, month = jun, number = 6, pages = {360--372}, pmid = {25915636}, posted-at = {2015-11-02 09:20:15}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Sequencing and beyond: integrating molecular 'omics' for microbial community profiling.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/25915636}, volume = 13, year = 2015 }