Artikel,

The physiological stimulus for the BarA sensor kinase

, , , und .
J Bacteriol, (Januar 2010)
DOI: 10.1128/JB.01685-09

Zusammenfassung

The two-component signal transduction system (TCS) BarA/UvrY activates transcription of CsrB and CsrC noncoding RNAs, which act by sequestering the RNA-binding global regulatory protein CsrA. Here, we show that the metabolic end-products formate and acetate provide a physiological stimulus for this TCS, and thus link post-transcriptional regulation by the Csr system to the metabolic state of the cell.

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