%0 Journal Article %1 cheever2011provenge %A Cheever, Martin A %A Higano, Celestia S %D 2011 %J Clinical Cancer Research %K cancer immuneSystem vaccine %N 11 %P 3520-3526 %R 10.1158/1078-0432.CCR-10-3126 %T PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine %U http://clincancerres.aacrjournals.org/content/17/11/3520 %V 17 %X Sipuleucel-T (PROVENGE; Dendreon) is the first therapeutic cancer vaccine to be approved by the U.S. Food and Drug Administration. In men who have metastatic castration-resistant prostate cancer with no or minimal symptoms, sipuleucel-T prolongs median survival by 4.1 months compared with results in those treated with placebo. At 3 years, the proportion of patients in the vaccine group who were alive was 50% higher than that in the control group (31.7% versus 21.7%, respectively). Sipuleucel-T, which is designed to elicit an immune response to prostatic acid phosphatase, uses the patient's own immune system to recognize and combat his cancer. Currently, no other agents are available that offer a survival benefit for this population of asymptomatic patients who have not been treated with chemotherapy, except for docetaxel (whose inherent toxicities often lead patients and physicians to delay administration until symptoms develop). Straightforward strategies to increase the efficacy of sipuleucel-T are likely to provide even greater benefit. The preclinical and clinical development of sipuleucel-T is reviewed, and approaches to enhance efficacy are considered herein

@article{cheever2011provenge, abstract = {Sipuleucel-T (PROVENGE; Dendreon) is the first therapeutic cancer vaccine to be approved by the U.S. Food and Drug Administration. In men who have metastatic castration-resistant prostate cancer with no or minimal symptoms, sipuleucel-T prolongs median survival by 4.1 months compared with results in those treated with placebo. At 3 years, the proportion of patients in the vaccine group who were alive was 50% higher than that in the control group (31.7% versus 21.7%, respectively). Sipuleucel-T, which is designed to elicit an immune response to prostatic acid phosphatase, uses the patient's own immune system to recognize and combat his cancer. Currently, no other agents are available that offer a survival benefit for this population of asymptomatic patients who have not been treated with chemotherapy, except for docetaxel (whose inherent toxicities often lead patients and physicians to delay administration until symptoms develop). Straightforward strategies to increase the efficacy of sipuleucel-T are likely to provide even greater benefit. The preclinical and clinical development of sipuleucel-T is reviewed, and approaches to enhance efficacy are considered herein}, added-at = {2017-12-02T23:33:28.000+0100}, author = {Cheever, Martin A and Higano, Celestia S}, biburl = {https://www.bibsonomy.org/bibtex/2bf72131a198b70b3c69f2841e2312a46/artheibault}, description = {This article describes a clinical trial of Sipuleucel-T, the first FDA-approved vaccine. This vaccine is intended for use on men with asymptomatic metastatic prostate cancer. The researchers found that it increased life expectancy by around four months, with no slowing of tumor progression. However, this vaccine is significant because it is the first to get FDA approval, and the hope was that more will follow.}, doi = {10.1158/1078-0432.CCR-10-3126}, interhash = {7b459ad5f603aeccbdda7ae0f4fdb990}, intrahash = {bf72131a198b70b3c69f2841e2312a46}, journal = {Clinical Cancer Research}, keywords = {cancer immuneSystem vaccine}, month = jun, number = 11, pages = {3520-3526}, timestamp = {2017-12-02T23:33:28.000+0100}, title = {PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine}, url = {http://clincancerres.aacrjournals.org/content/17/11/3520}, volume = 17, year = 2011 }