%0 Journal Article %1 GomezdeAguero2016Maternal %A Gomez de Agüero, Mercedes %A Ganal-Vonarburg, Stephanie C. %A Fuhrer, Tobias %A Rupp, Sandra %A Uchimura, Yasuhiro %A Li, Hai %A Steinert, Anna %A Heikenwalder, Mathias %A Hapfelmeier, Siegfried %A Sauer, Uwe %A McCoy, Kathy D. %A Macpherson, Andrew J. %D 2016 %J Science (New York, N.Y.) %K gut-microbiome immune-system %N 6279 %P 1296--1302 %R 10.1126/science.aad2571 %T The maternal microbiota drives early postnatal innate immune development. %U http://dx.doi.org/10.1126/science.aad2571 %V 351 %X Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female mice, we show that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increases intestinal group 3 innate lymphoid cells and F4/80(+)CD11c(+) mononuclear cells in the pups. Maternal colonization reprograms intestinal transcriptional profiles of the offspring, including increased expression of genes encoding epithelial antibacterial peptides and metabolism of microbial molecules. Some of these effects are dependent on maternal antibodies that potentially retain microbial molecules and transmit them to the offspring during pregnancy and in milk. Pups born to mothers transiently colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes. Copyright \copyright 2016, American Association for the Advancement of Science.

@article{GomezdeAguero2016Maternal, abstract = {Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female mice, we show that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increases intestinal group 3 innate lymphoid cells and {F4/80(+)CD11c}(+) mononuclear cells in the pups. Maternal colonization reprograms intestinal transcriptional profiles of the offspring, including increased expression of genes encoding epithelial antibacterial peptides and metabolism of microbial molecules. Some of these effects are dependent on maternal antibodies that potentially retain microbial molecules and transmit them to the offspring during pregnancy and in milk. Pups born to mothers transiently colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes. Copyright {\copyright} 2016, American Association for the Advancement of Science.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Gomez de Ag\"{u}ero, Mercedes and Ganal-Vonarburg, Stephanie C. and Fuhrer, Tobias and Rupp, Sandra and Uchimura, Yasuhiro and Li, Hai and Steinert, Anna and Heikenwalder, Mathias and Hapfelmeier, Siegfried and Sauer, Uwe and McCoy, Kathy D. and Macpherson, Andrew J.}, biburl = {https://www.bibsonomy.org/bibtex/213dafc0b9aea55662db8a0d5b61cad79/karthikraman}, citeulike-article-id = {13985998}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.aad2571}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/26989247}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=26989247}, day = 18, doi = {10.1126/science.aad2571}, interhash = {847d343dc49ba061cf1ed065becdc884}, intrahash = {13dafc0b9aea55662db8a0d5b61cad79}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {gut-microbiome immune-system}, month = mar, number = 6279, pages = {1296--1302}, pmid = {26989247}, posted-at = {2016-03-23 11:36:15}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {The maternal microbiota drives early postnatal innate immune development.}, url = {http://dx.doi.org/10.1126/science.aad2571}, volume = 351, year = 2016 }