%0 Journal Article %1 Virginia:2000:Curr-Genet:10905426 %A Virginia, M %A Appleyard, C L %A McPheat, W L %A Stark, M J %D 2000 %J Curr Genet %K imported %N 6 %P 364-372 %T A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans %U http://www.ncbi.nlm.nih.gov/pubmed/10905426?dopt=Abstract %V 37 %X We have characterised a-novel Aspergillus nidulans gene encoding a 'two-component' signalling protein (tcsA). tcsA encodes both a histidine kinase domain and a response regulator domain similar to those found in bacterial, lower eukaryotic and plant members of the two-component family of proteins, while two PAS domains in the amino-terminal region of the predicted tcsA product may monitor the signal which regulates a tcsA histidine kinase-response regulator phosphorelay. While tcsA is nonessential for vegetative growth, cells lacking the gene are unable to produce conidia on standard Aspergillus growth media. However, tcsA is not absolutely required for production since this defect is suppressed by growth on 1 M sorbitol.

@article{Virginia:2000:Curr-Genet:10905426, abstract = {We have characterised a-novel Aspergillus nidulans gene encoding a 'two-component' signalling protein (tcsA). tcsA encodes both a histidine kinase domain and a response regulator domain similar to those found in bacterial, lower eukaryotic and plant members of the two-component family of proteins, while two PAS domains in the amino-terminal region of the predicted tcsA product may monitor the signal which regulates a tcsA histidine kinase-response regulator phosphorelay. While tcsA is nonessential for vegetative growth, cells lacking the gene are unable to produce conidia on standard Aspergillus growth media. However, tcsA is not absolutely required for production since this defect is suppressed by growth on 1 M sorbitol.}, added-at = {2008-12-13T17:23:06.000+0100}, author = {Virginia, M and Appleyard, C L and McPheat, W L and Stark, M J}, biburl = {https://www.bibsonomy.org/bibtex/27d5ade529c371289cb9d5ce1a0e4254e/ben8bibsonomy}, description = {A novel 'two-component' protein containing histidi...[Curr Genet. 2000] - PubMed Result}, interhash = {9257098c8ba3721b2018456374bdf345}, intrahash = {7d5ade529c371289cb9d5ce1a0e4254e}, journal = {Curr Genet}, keywords = {imported}, month = Jun, number = 6, pages = {364-372}, pmid = {10905426}, timestamp = {2008-12-13T17:23:06.000+0100}, title = {A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10905426?dopt=Abstract}, volume = 37, year = 2000 }