Аннотация
Advances in sequencing technologies and increased access to sequencing
services have led to renewed interest in sequence and genome assembly. Concurrently,
new applications for sequencing have emerged, including gene expression analysis,
discovery of genomic variants and metagenomics, and each of these has different needs
and challenges in terms of assembly. We survey the theoretical foundations that underlie
modern assembly and highlight the options and practical trade-offs that need to be
considered, focusing on how individual features address the needs of specific
applications. We also review key software and the interplay between experimental
design and efficacy of assembly
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