%0 Journal Article %1 Chernenko2006 %A Chernenko, Susan M. %A Humar, Atul %A Hutcheon, Michael %A Chow, Chung-Wai %A Chaparro, Cecilia %A Keshavjee, Shaf %A Singer, Lianne G. %D 2006 %J J Heart Lung Transplant %K transplantation abscessus mycobacteria %N 12 %P 1447--1455 %R 10.1016/j.healun.2006.09.003 %T Mycobacterium abscessus infections in lung transplant recipients: the international experience. %U http://dx.doi.org/10.1016/j.healun.2006.09.003 %V 25 %X The clinical significance of Mycobacterium abscessus infection in the lung transplant population is not well understood.An international survey was performed to determine the incidence and clinical outcomes of M abscessus infections before and after lung transplantation.Thirty-one (50\%) of the 62 transplant centers affiliated with the International Society of Heart and Lung Transplantation responded to the survey. Of 5,200 transplants performed, 17 patients (0.33\%) (M/F, 12:5) were identified with M abscessus after transplantation. Two patients had respiratory colonization before lung transplantation. Post-transplantation M abscessus infections occurred in the pulmonary allograft in 12, in skin/soft tissue in 3, or both in 2. Median time to diagnosis after transplantation was 18.5 months (range, 1-111 months). Therapies included multiple antibiotics in 16, surgical débridement in 2, interferon-gamma in 1, or no therapy owing to presumed colonization in 1. Eleven (73\%) of 16 treated patients had a radiologic or microbiologic response to treatment. Concurrent infections were common, with Aspergillus (n = 8) and Pseudomonas aeruginosa (n = 5) most frequently seen. Death in 2 patients was attributed to M abscessus. Ten of 17 patients are alive and considered cured.M abscessus infection in the lung transplant recipient is uncommon and challenging; however, successful treatment can occur. Prolonged combination anti-microbial therapy is required for pulmonary involvement, and surgical débridement is recommended for cutaneous lesions. Concurrent infections are common and may contribute to mortality in this immunosuppressed population.

@article{Chernenko2006, abstract = {The clinical significance of Mycobacterium abscessus infection in the lung transplant population is not well understood.An international survey was performed to determine the incidence and clinical outcomes of M abscessus infections before and after lung transplantation.Thirty-one (50\%) of the 62 transplant centers affiliated with the International Society of Heart and Lung Transplantation responded to the survey. Of 5,200 transplants performed, 17 patients (0.33\%) (M/F, 12:5) were identified with M abscessus after transplantation. Two patients had respiratory colonization before lung transplantation. Post-transplantation M abscessus infections occurred in the pulmonary allograft in 12, in skin/soft tissue in 3, or both in 2. Median time to diagnosis after transplantation was 18.5 months (range, 1-111 months). Therapies included multiple antibiotics in 16, surgical débridement in 2, interferon-gamma in 1, or no therapy owing to presumed colonization in 1. Eleven (73\%) of 16 treated patients had a radiologic or microbiologic response to treatment. Concurrent infections were common, with Aspergillus (n = 8) and Pseudomonas aeruginosa (n = 5) most frequently seen. Death in 2 patients was attributed to M abscessus. Ten of 17 patients are alive and considered cured.M abscessus infection in the lung transplant recipient is uncommon and challenging; however, successful treatment can occur. Prolonged combination anti-microbial therapy is required for pulmonary involvement, and surgical débridement is recommended for cutaneous lesions. Concurrent infections are common and may contribute to mortality in this immunosuppressed population.}, added-at = {2012-03-13T01:41:29.000+0100}, author = {Chernenko, Susan M. and Humar, Atul and Hutcheon, Michael and Chow, Chung-Wai and Chaparro, Cecilia and Keshavjee, Shaf and Singer, Lianne G.}, biburl = {https://www.bibsonomy.org/bibtex/29a0afb09f9ecec48f83898dbd213031c/aorchid}, doi = {10.1016/j.healun.2006.09.003}, file = {:ID_General/TransplantClinical/JHLT.25.1447.Mabscessus.pdf:PDF}, groups = {public}, institution = {Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.}, interhash = {965472580957c0b5a60c9631e9319d24}, intrahash = {9a0afb09f9ecec48f83898dbd213031c}, journal = {J Heart Lung Transplant}, keywords = {transplantation abscessus mycobacteria}, language = {eng}, medline-pst = {ppublish}, month = Dec, number = 12, pages = {1447--1455}, pii = {S1053-2498(06)00641-3}, pmid = {17178340}, timestamp = {2012-03-13T01:41:29.000+0100}, title = {Mycobacterium abscessus infections in lung transplant recipients: the international experience.}, url = {http://dx.doi.org/10.1016/j.healun.2006.09.003}, username = {aorchid}, volume = 25, year = 2006 }