Аннотация
There is a growing body of experimental evidence suggesting that the
Ca(2+) signaling in ventricular myocytes is characterized by a high
gradient near the cell membrane and a more uniform Ca(2+) distribution
in the cell interior 1--7. An important reason for this phenomenon
might be that in these cells the t-tubular system forms a network
of extracellular space, extending deep into the cell interior. This
allows the electrical signal, that propagates rapidly along the cell
membrane, to reach the vicinity of the sarcoplasmic reticulum (SR),
where intracellular Ca(2+) required for myofilament activation is
stored 1, 8--11. Early studies of cardiac muscle showed that
the t-tubules are found at intervals of about 2 lm along the longitudinal
cell axis in close proximity to the Z-disks of the sarcomeres 12.
Subsequent studies have demonstrated that the t-tubular system has
also longitudinal extensions 9--11, 13.
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