,
Polymeric drugs based on conjugates of synthetic and natural macromolecules. I. Synthesis and physico-chemical characterisation.
J Control Release, 64 (1-3): 63-79 (2000)
Аннотация
This paper describes the synthesis, physico-chemical characteristics
and results of selected biological tests of conjugates of antibodies
or proteins with poly(HPMA) or with poly(HPMA) carriers of anti-cancer
drug doxorubicin, designed for targeted cancer therapy. Two types
of conjugates differing in the method of conjugation of polymer with
protein were synthesized. In the first, protein is attached to the
polymer via an oligopeptide sequence in the side chain of the polymer
backbone and, in the second, the polymer is attached to protein via
its end-chain functional group. Conjugation of an antibody with poly(HPMA)
does not influence the binding activity of the antibody for cell
surface antigen. The physico-chemical characteristics and biological
activity of both systems depend on the detailed structure of the
polymer, the type of antibody or protein moiety and the structure
of the whole system.
тэги
- ;
- acid
- agents/*pharmacokinetics
- amino
- animals
- antibodies/chemistry/metabolism
- antigens,
- antineoplastic
- balb
- binding
- c
- c57bl
- carriers/chemistry
- cells,
- cultured
- data
- doxorubicin/*pharmacokinetics
- drug
- factors
- female
- gov't
- in
- inbred
- lymphoma/*drug
- macromolecular
- male
- methacrylates/chemical
- mice
- mice,
- molecular
- non-u.s.
- oligopeptides/chemistry
- polymers/chemistry
- proteins/*chemistry
- relationship
- research
- sequence
- sites
- structure-activity
- substances
- support,
- surface/metabolism
- synthesis/*chemistry
- t-lymphocytes
- therapy
- time
- tumor
- vitro
