%0 Journal Article %1 bjorkandersarscov2specific %A Björkander, Sophia %A Du, Likun %A Zuo, Fanglei %A Ekström, Sandra %A Wang, Yating %A Wan, Hui %A Sherina, Natalia %A Schoutens, Lisanne %A Andréll, Juni %A Andersson, Niklas %A Georgelis, Antonios %A Bergström, Anna %A Marcotte, Harold %A Kull, Inger %A Hammarström, Lennart %A Melén, Erik %A Pan-Hammarström, Qiang %A Almqvist, Catarina %A Ballardini, Natalia %A Brodin, Petter %A Castel, Anna %A Hallberg, Jenny %A Jansson, Christer %A Kere, Maura %A Lauber, André %A Lövquist, Alexandra %A Mjösberg, Jenny %A Mogensen, Ida %A Palmberg, Lena %A Pershagen, Göran %A Roxhed, Niclas %A Schwenk, Jochen %D 2021 %I Elsevier %J Journal of Allergy and Clinical Immunology %K SARS-Cov-2 %N 0 %R 10.1016/j.jaci.2021.10.014 %T SARS-CoV-2–specific B- and T-cell immunity in a population-based study of young Swedish adults %U https://www.jacionline.org/article/S0091-6749(21)01626-2/fulltext %V 0 %X <h3>Background</h3><p>Young adults are now considered major spreaders of coronavirus disease 2019 (COVID-19) disease. Although most young individuals experience mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists in young adults remain unclear.</p><h3>Objective</h3><p>We conducted a population-based study on humoral and cellular immunity to SARS-CoV-2 and explored COVID-19 disease characteristics in young adults.</p><h3>Methods</h3><p>We invited participants from the Swedish BAMSE (Barn Children, Allergy Milieu, Stockholm, Epidemiology) birth cohort (age 24-27 years) to take part in a COVID-19 follow-up. From 980 participants (October 2020 to June 2021), we here present data on SARS-CoV-2 receptor-binding domain–specific IgM, IgA, and IgG titers measured by ELISA and on symptoms and epidemiologic factors associated with seropositivity. Further, SARS-CoV-2–specific memory B- and T-cell responses were detected for a subpopulation (n = 108) by ELISpot and FluoroSpot.</p><h3>Results</h3><p>A total of 28.4% of subjects were seropositive, of whom 18.4% were IgM single positive. One in 7 seropositive subjects was asymptomatic. Seropositivity was associated with use of public transport, but not with sex, asthma, rhinitis, IgE sensitization, smoking, or body mass index. In a subset of representative samples, 20.7% and 35.0% had detectable SARS-CoV-2 specific B- and T-cell responses, respectively. B- and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.</p><h3>Conclusions</h3><p>Assessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults indicates that the large-scale vaccination campaign should be continued.</p>

@article{bjorkandersarscov2specific, abstract = {<h3>Background</h3><p>Young adults are now considered major spreaders of coronavirus disease 2019 (COVID-19) disease. Although most young individuals experience mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists in young adults remain unclear.</p><h3>Objective</h3><p>We conducted a population-based study on humoral and cellular immunity to SARS-CoV-2 and explored COVID-19 disease characteristics in young adults.</p><h3>Methods</h3><p>We invited participants from the Swedish BAMSE (Barn [Children], Allergy Milieu, Stockholm, Epidemiology) birth cohort (age 24-27 years) to take part in a COVID-19 follow-up. From 980 participants (October 2020 to June 2021), we here present data on SARS-CoV-2 receptor-binding domain–specific IgM, IgA, and IgG titers measured by ELISA and on symptoms and epidemiologic factors associated with seropositivity. Further, SARS-CoV-2–specific memory B- and T-cell responses were detected for a subpopulation (n = 108) by ELISpot and FluoroSpot.</p><h3>Results</h3><p>A total of 28.4% of subjects were seropositive, of whom 18.4% were IgM single positive. One in 7 seropositive subjects was asymptomatic. Seropositivity was associated with use of public transport, but not with sex, asthma, rhinitis, IgE sensitization, smoking, or body mass index. In a subset of representative samples, 20.7% and 35.0% had detectable SARS-CoV-2 specific B- and T-cell responses, respectively. B- and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.</p><h3>Conclusions</h3><p>Assessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults indicates that the large-scale vaccination campaign should be continued.</p>}, added-at = {2021-12-10T22:40:53.000+0100}, author = {Björkander, Sophia and Du, Likun and Zuo, Fanglei and Ekström, Sandra and Wang, Yating and Wan, Hui and Sherina, Natalia and Schoutens, Lisanne and Andréll, Juni and Andersson, Niklas and Georgelis, Antonios and Bergström, Anna and Marcotte, Harold and Kull, Inger and Hammarström, Lennart and Melén, Erik and Pan-Hammarström, Qiang and Almqvist, Catarina and Ballardini, Natalia and Brodin, Petter and Castel, Anna and Hallberg, Jenny and Jansson, Christer and Kere, Maura and Lauber, André and Lövquist, Alexandra and Mjösberg, Jenny and Mogensen, Ida and Palmberg, Lena and Pershagen, Göran and Roxhed, Niclas and Schwenk, Jochen}, biburl = {https://www.bibsonomy.org/bibtex/23fd29e2d57bbd4fd9abd9087cfc2bf67/lkanth}, description = {SARS-CoV-2–specific B- and T-cell immunity in a population-based study of young Swedish adults - Journal of Allergy and Clinical Immunology}, doi = {10.1016/j.jaci.2021.10.014}, interhash = {a57ddda662befe0508bafffbdfc59528}, intrahash = {3fd29e2d57bbd4fd9abd9087cfc2bf67}, issn = {0091-6749, 1097-6825}, journal = {Journal of Allergy and Clinical Immunology}, keywords = {SARS-Cov-2}, number = 0, publisher = {Elsevier}, timestamp = {2021-12-10T22:40:53.000+0100}, title = {SARS-CoV-2–specific B- and T-cell immunity in a population-based study of young Swedish adults}, type = {Article}, url = {https://www.jacionline.org/article/S0091-6749(21)01626-2/fulltext}, volume = 0, year = 2021 }