%0 Journal Article %1 newAB %A Ling, Losee L. %A Schneider, Tanja %A Peoples, Aaron J. %A Spoering, Amy L. %A Engels, Ina %A Conlon, Brian P. %A Mueller, Anna %A Schaberle, Till F. %A Hughes, Dallas E. %A Epstein, Slava %A Jones, Michael %A Lazarides, Linos %A Steadman, Victoria A. %A Cohen, Douglas R. %A Felix, Cintia R. %A Fetterman, K. Ashley %A Millett, William P. %A Nitti, Anthony G. %A Zullo, Ashley M. %A Chen, Chao %A Lewis, Kim %D 2015 %I Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. %J Nature %K masters %N 7535 %P 455--459 %T A new antibiotic kills pathogens without detectable resistance %U http://dx.doi.org/10.1038/nature14098 %V 517 %X Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.

@article{newAB, abstract = {Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.}, added-at = {2015-03-22T01:17:46.000+0100}, author = {Ling, Losee L. and Schneider, Tanja and Peoples, Aaron J. and Spoering, Amy L. and Engels, Ina and Conlon, Brian P. and Mueller, Anna and Schaberle, Till F. and Hughes, Dallas E. and Epstein, Slava and Jones, Michael and Lazarides, Linos and Steadman, Victoria A. and Cohen, Douglas R. and Felix, Cintia R. and Fetterman, K. Ashley and Millett, William P. and Nitti, Anthony G. and Zullo, Ashley M. and Chen, Chao and Lewis, Kim}, biburl = {https://www.bibsonomy.org/bibtex/27854e8025f2707af2827ccb6b72c9d04/ross_mck}, description = {A new antibiotic kills pathogens without detectable resistance : Nature : Nature Publishing Group}, interhash = {af66ba1dd388c9abe3c14ab7c9a2e5ac}, intrahash = {7854e8025f2707af2827ccb6b72c9d04}, issn = {00280836}, journal = {Nature}, keywords = {masters}, month = jan, number = 7535, pages = {455--459}, publisher = {Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.}, timestamp = {2015-03-22T01:17:46.000+0100}, title = {A new antibiotic kills pathogens without detectable resistance}, url = {http://dx.doi.org/10.1038/nature14098}, volume = 517, year = 2015 }