Abstract
Significant tissue structures exist in cardiac ventricular tissue,
which are of supracellular dimension. It is hypothesized that these
tissue structures contribute to the discontinuous spread of electrical
activation, may contribute to arrhythmogenesis, and also provide
a substrate for effective cardioversion. However, the influences
of these mesoscale tissue structures in intact ventricular tissue
are difficult to understand solely on the basis of experimental measurement.
Current measurement technology is able to record at both the macroscale
tissue level and the microscale cellular or subcellular level, but
to date it has not been possible to obtain large volume, direct measurements
at the mesoscales. To bridge this scale gap in experimental measurements,
we use tissue-specific structure and mathematical modeling. Our models,
which can incorporate ion channel models at the cell level into the
reaction-diffusion equations at the tissue level, have enabled us
to consider key hypotheses regarding discontinuous activation.
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