%0 Journal Article %1 Msall1994 %A Msall, M. E. %A Buck, G. M. %A Rogers, B. T. %A Merke, D. P. %A Wan, C. C. %A Catanzaro, N. L. %A Zorn, W. A. %D 1994 %J J Perinatol %K Blindness; Cerebral Palsy; Child Development; Cohort Studies; Female; Follow-Up Gestational Age; Humans; Infant Mortality; Infant, Newborn; Premature; Male; Mental Retardation; Nervous System Diseases; Pulmonary Surfactants; Regression Analysis; Risk F; actors %N 1 %P 41--47 %T Multivariate risks among extremely premature infants. %V 14 %X This study was designed to identify risk factors for mortality and morbidity of extremely premature infants born in the surfactant era. The study cohort included 194 infants born at < 29 weeks' gestation at one regional tertiary center between 1983 and 1986. Forty-one infants died. Blinded neurodevelopmental assessments were performed on 149 of 153 (97\%) survivors at a mean age of 52 months. Thirty-one (21\%) survivors had major impairments: 15 had mental retardation, 8 had multiple impairments, 7 had cerebral palsy, and 1 was blind. Logistic regression analysis identifies five significant risk factors for mortality: grade III or IV intraventricular hemorrhage, birth weight < 800 gm, 5-minute Apgar score < or = 3, male sex, and absence of surfactant therapy. Significant risk factors for any major impairment included sepsis (relative risks RR = 6.4), male sex (RR = 3.1), and nonwhite race (RR = 2.8). Hydrocephalus requiring shunting was a significant risk factor for cerebral palsy (RR = 16.4) and neonatal retardation (RR = 16.0). Nonwhite race (RR = 7.3), sepsis (RR = 6.8), and male sex (RR = 3.7) also were significant risk factors for mental retardation. Confirmation of these risk factors should facilitate development of targeted interventions for optimizing long-term outcome.

@article{Msall1994, abstract = {This study was designed to identify risk factors for mortality and morbidity of extremely premature infants born in the surfactant era. The study cohort included 194 infants born at < 29 weeks' gestation at one regional tertiary center between 1983 and 1986. Forty-one infants died. Blinded neurodevelopmental assessments were performed on 149 of 153 (97\%) survivors at a mean age of 52 months. Thirty-one (21\%) survivors had major impairments: 15 had mental retardation, 8 had multiple impairments, 7 had cerebral palsy, and 1 was blind. Logistic regression analysis identifies five significant risk factors for mortality: grade III or IV intraventricular hemorrhage, birth weight < 800 gm, 5-minute Apgar score < or = 3, male sex, and absence of surfactant therapy. Significant risk factors for any major impairment included sepsis (relative risks [RR] = 6.4), male sex (RR = 3.1), and nonwhite race (RR = 2.8). Hydrocephalus requiring shunting was a significant risk factor for cerebral palsy (RR = 16.4) and neonatal retardation (RR = 16.0). Nonwhite race (RR = 7.3), sepsis (RR = 6.8), and male sex (RR = 3.7) also were significant risk factors for mental retardation. Confirmation of these risk factors should facilitate development of targeted interventions for optimizing long-term outcome.}, added-at = {2014-07-19T20:49:11.000+0200}, author = {Msall, M. E. and Buck, G. M. and Rogers, B. T. and Merke, D. P. and Wan, C. C. and Catanzaro, N. L. and Zorn, W. A.}, biburl = {https://www.bibsonomy.org/bibtex/2c5bfd34862c1e896f2ca77f792660b77/ar0berts}, groups = {public}, interhash = {bcbd3c7cb5e39cb68296e7e876692920}, intrahash = {c5bfd34862c1e896f2ca77f792660b77}, journal = {J Perinatol}, keywords = {Blindness; Cerebral Palsy; Child Development; Cohort Studies; Female; Follow-Up Gestational Age; Humans; Infant Mortality; Infant, Newborn; Premature; Male; Mental Retardation; Nervous System Diseases; Pulmonary Surfactants; Regression Analysis; Risk F; actors}, number = 1, pages = {41--47}, pmid = {8169677}, timestamp = {2014-07-19T20:49:11.000+0200}, title = {Multivariate risks among extremely premature infants.}, username = {ar0berts}, volume = 14, year = 1994 }