%0 Journal Article %1 peter2012distinguishing %A Peter, Benjamin M. %A Huerta-Sanchez, Emilia %A Nielsen, Rasmus %D 2012 %I Public Library of Science %J PLoS Genet %K age_of_allele approximate_bayesian_computation methods selective_sweep standing_variation %N 10 %P e1003011 %R 10.1371/journal.pgen.1003011 %T Distinguishing between Selective Sweeps from Standing Variation and from a De Novo Mutation %U http://dx.doi.org/10.1371%2Fjournal.pgen.1003011 %V 8 %X Considerable effort has been devoted to detecting genes that are under natural selection, and hundreds of such genes have been identified in previous studies. Here, we present a method for extending these studies by inferring parameters, such as selection coefficients and the time when a selected variant arose. Of particular interest is the question whether the selective pressure was already present when the selected variant was first introduced into a population. In this case, the variant would be selected right after it originated in the population, a process we call selection from a <italic>de novo</italic> mutation. We contrast this with selection from standing variation, where the selected variant predates the selective pressure. We present a method to distinguish these two scenarios, test its accuracy, and apply it to seven human genes. We find three genes, ADH1B, EDAR, and LCT, that were presumably selected from a de novo mutation and two other genes, ASPM and PSCA, which we infer to be under selection from standing variation.

@article{peter2012distinguishing, abstract = {Considerable effort has been devoted to detecting genes that are under natural selection, and hundreds of such genes have been identified in previous studies. Here, we present a method for extending these studies by inferring parameters, such as selection coefficients and the time when a selected variant arose. Of particular interest is the question whether the selective pressure was already present when the selected variant was first introduced into a population. In this case, the variant would be selected right after it originated in the population, a process we call selection from a <italic>de novo</italic> mutation. We contrast this with selection from standing variation, where the selected variant predates the selective pressure. We present a method to distinguish these two scenarios, test its accuracy, and apply it to seven human genes. We find three genes, ADH1B, EDAR, and LCT, that were presumably selected from a de novo mutation and two other genes, ASPM and PSCA, which we infer to be under selection from standing variation.}, added-at = {2013-01-18T23:31:59.000+0100}, author = {Peter, Benjamin M. and Huerta-Sanchez, Emilia and Nielsen, Rasmus}, biburl = {https://www.bibsonomy.org/bibtex/2fa320783ee2e13efda16a47602f3edd3/peter.ralph}, doi = {10.1371/journal.pgen.1003011}, interhash = {c849d2265745804f8bd1bb909f2fb187}, intrahash = {fa320783ee2e13efda16a47602f3edd3}, journal = {PLoS Genet}, keywords = {age_of_allele approximate_bayesian_computation methods selective_sweep standing_variation}, month = {10}, number = 10, pages = {e1003011}, publisher = {Public Library of Science}, timestamp = {2013-01-29T19:22:24.000+0100}, title = {Distinguishing between Selective Sweeps from Standing Variation and from a {\it De Novo} Mutation}, url = {http://dx.doi.org/10.1371%2Fjournal.pgen.1003011}, volume = 8, year = 2012 }