%0 Journal Article %1 rodriguezsystemslevel %A Rodriguez, Lucie %A Pekkarinen, Pirkka T. %A Lakshmikanth, Tadepally %A Tan, Ziyang %A Consiglio, Camila Rosat %A Pou, Christian %A Chen, Yang %A Mugabo, Constantin Habimana %A Nguyen, Ngoc Anh %A Nowlan, Kirsten %A Strandin, Tomas %A Levanov, Lev %A Mikes, Jaromir %A Wang, Jun %A Kantele, Anu %A Hepojoki, Jussi %A Vapalahti, Olli %A Heinonen, Santtu %A Kekäläinen, Eliisa %A Brodin, Petter %B Cell Reports Medicine %D 2020 %I Elsevier %J Cell Reports Medicine %K Covid-19 %R 10.1016/j.xcrm.2020.100078 %T Systems-level immunomonitoring from acute to recovery phase of severe COVID-19 %U https://doi.org/10.1016/j.xcrm.2020.100078 %X Severe disease of SARS-CoV2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome, rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses required to capture cellular interactions. Here we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFN? ? Eosinophil axis activated prior to lung hyperinflammation and changes in cell-cell coregulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.

@article{rodriguezsystemslevel, abstract = {Severe disease of SARS-CoV2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome, rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses required to capture cellular interactions. Here we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFN? ? Eosinophil axis activated prior to lung hyperinflammation and changes in cell-cell coregulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.}, added-at = {2020-08-10T17:27:08.000+0200}, author = {Rodriguez, Lucie and Pekkarinen, Pirkka T. and Lakshmikanth, Tadepally and Tan, Ziyang and Consiglio, Camila Rosat and Pou, Christian and Chen, Yang and Mugabo, Constantin Habimana and Nguyen, Ngoc Anh and Nowlan, Kirsten and Strandin, Tomas and Levanov, Lev and Mikes, Jaromir and Wang, Jun and Kantele, Anu and Hepojoki, Jussi and Vapalahti, Olli and Heinonen, Santtu and Kekäläinen, Eliisa and Brodin, Petter}, biburl = {https://www.bibsonomy.org/bibtex/25e625bdd6d048ff6bfd976ccea21d038/lkanth}, booktitle = {Cell Reports Medicine}, comment = {doi: 10.1016/j.xcrm.2020.100078}, description = {Systems-level immunomonitoring from acute to recovery phase of severe COVID-19: Cell Reports Medicine}, doi = {10.1016/j.xcrm.2020.100078}, interhash = {db93860d46e9ee423aae21078581315d}, intrahash = {5e625bdd6d048ff6bfd976ccea21d038}, issn = {26663791}, journal = {Cell Reports Medicine}, keywords = {Covid-19}, publisher = {Elsevier}, timestamp = {2020-08-10T17:27:08.000+0200}, title = {Systems-level immunomonitoring from acute to recovery phase of severe COVID-19}, url = {https://doi.org/10.1016/j.xcrm.2020.100078}, year = 2020 }