%0 Journal Article %1 Karlsson2009398 %A Karlsson, Sari %A Nyberg, Lars %A Karlsson, Per %A Fischer, Håkan %A Thilers, Petra %A MacDonald, Stuart %A Brehmer, Yvonne %A Rieckmann, Anna %A Halldin, Christer %A Farde, Lars %A Bäckman, Lars %D 2009 %J NeuroImage %K dopamine executive_function pfc striatum %N 2 %P 398--404 %R DOI: 10.1016/j.neuroimage.2009.06.030 %T Modulation of striatal dopamine D1 binding by cognitive processing %U http://www.sciencedirect.com/science/article/B6WNP-4WJBBVS-6/2/a3d7ed036cea77ddc64737f7330d1eb7 %V 48 %X There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30 years) and 20 older (65-75 years) persons who underwent two 11C SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system.

@article{Karlsson2009398, abstract = {There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30 years) and 20 older (65-75 years) persons who underwent two [11C] SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system.}, added-at = {2009-09-10T09:49:53.000+0200}, author = {Karlsson, Sari and Nyberg, Lars and Karlsson, Per and Fischer, Håkan and Thilers, Petra and MacDonald, Stuart and Brehmer, Yvonne and Rieckmann, Anna and Halldin, Christer and Farde, Lars and Bäckman, Lars}, biburl = {https://www.bibsonomy.org/bibtex/2e79f6d5792b753a532f0b64967c61c44/flint_riemen}, description = {ScienceDirect - NeuroImage : Modulation of striatal dopamine D1 binding by cognitive processing}, doi = {DOI: 10.1016/j.neuroimage.2009.06.030}, interhash = {ee407bab550601926aca6805c0be9ddb}, intrahash = {e79f6d5792b753a532f0b64967c61c44}, issn = {1053-8119}, journal = {NeuroImage}, keywords = {dopamine executive_function pfc striatum}, number = 2, pages = {398--404}, timestamp = {2010-01-04T17:25:26.000+0100}, title = {Modulation of striatal dopamine D1 binding by cognitive processing}, url = {http://www.sciencedirect.com/science/article/B6WNP-4WJBBVS-6/2/a3d7ed036cea77ddc64737f7330d1eb7}, volume = 48, year = 2009 }