%0 Journal Article %1 Fran_2001_9 %A Franks, Kevin M. %A Bartol, Thomas M. %A Sejnowski, Terrence J. %D 2001 %J Neurocomputing %K Buffering, Calcium, Calmodulin, Frequency-dependence, Long-term potentiation %P 9--16 %T An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines %U http://www.sciencedirect.com/science/article/B6V10-435KK2K-3/2/68fbcdbb174b11111fbf19a8709a455e %V 38-40 %X Pairing action potentials in synaptically coupled cortical pyramidal cells induces LTP in a frequency-dependent manner (H. Markram et al., Science 275 (1997) 213). Using MCell, which simulated the 3D geometry of the spine and the diffusion and binding of Ca$^2+$, we show that pairing five EPSPs and back-propagating action potentials results in a Ca$^2+$ influx into a model dendritic spine that is largely frequency independent but leads to a frequency-dependent activation of postsynaptic calmodulin. Furthermore, we show how altering the availability of calmodulin and the calcium-binding capacity can alter the efficacy and potency of the frequency-response curve. The model shows how the cell can regulate its plasticity by buffering Ca$^2+$ signals.

@article{Fran_2001_9, abstract = {Pairing action potentials in synaptically coupled cortical pyramidal cells induces LTP in a frequency-dependent manner (H. Markram et al., Science 275 (1997) 213). Using MCell, which simulated the 3D geometry of the spine and the diffusion and binding of {C}a$^{2+}$, we show that pairing five EPSPs and back-propagating action potentials results in a {C}a$^{2+}$ influx into a model dendritic spine that is largely frequency independent but leads to a frequency-dependent activation of postsynaptic calmodulin. Furthermore, we show how altering the availability of calmodulin and the calcium-binding capacity can alter the efficacy and potency of the frequency-response curve. The model shows how the cell can regulate its plasticity by buffering {C}a$^{2+}$ signals.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Franks, Kevin M. and Bartol, Thomas M. and Sejnowski, Terrence J.}, biburl = {https://www.bibsonomy.org/bibtex/2719b77b93606ea9c9dafa6445f5c6df0/hake}, description = {The whole bibliography file I use.}, file = {Fran_2001_9.pdf:Fran_2001_9.pdf:PDF}, interhash = {f3e1250eba01dbe6d98007f54f807d1d}, intrahash = {719b77b93606ea9c9dafa6445f5c6df0}, journal = {Neurocomputing}, keywords = {Buffering, Calcium, Calmodulin, Frequency-dependence, Long-term potentiation}, month = {June}, pages = {9--16}, timestamp = {2009-06-03T11:21:12.000+0200}, title = {An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines}, url = {http://www.sciencedirect.com/science/article/B6V10-435KK2K-3/2/68fbcdbb174b11111fbf19a8709a455e}, volume = {38-40}, year = 2001 }