%0 Journal Article %1 Schmitz.1995.Theeffect %A Schmitz, S. %A Franke, H. %A Wichmann, Heinz-Erich %A Diehl, Volker %D 1995 %J British journal of haematology %K IMISE-Publikationen %N 1 %P 41–47 %T The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis %V 90 %X Human cyclic neutropenia (CN) is a rare haematological disorder characterized by oscillations of blood neutrophils at subnormal levels with a stable period of approximately 21 d. During the phase of severe neutropenia (neutrophils < 250 cells/microliters), which last 4-10 d, the patients are endangered by serious infections. Several authors report that continuous G-CSF application can elevate the blood neutrophils to such a level that the risk of infections is significantly reduced. Although the characteristic cycles are not eliminated by G-CSF, the period of the oscillations is shortened to 12-14 d. Based on a previously proposed computer-simulation model of human CN, the effects of continuous G-CSF application on CN are studied. It is shown how the known different cell-kinetic effects of G-CSF on granulopoiesis explain the clinical data in CN. The reduced length of the cycles emerges as a result of the transit time reduction of the post-mitotic granulopoietic cells by G-CSF. The measured increase of the neutrophil maxima is reproduced by the additional mitoses of the immature granulopoietic bone marrow cells induced by G-CSF. The slight elevation of the neutrophil nadirs can be attributed to a weak effect of G-CSF on the assumed underlying defect in CN (an abnormally small variance of the granulopoietic bone-marrow transit time).

@article{Schmitz.1995.Theeffect, abstract = {Human cyclic neutropenia (CN) is a rare haematological disorder characterized by oscillations of blood neutrophils at subnormal levels with a stable period of approximately 21 d. During the phase of severe neutropenia (neutrophils < 250 cells/microliters), which last 4-10 d, the patients are endangered by serious infections. Several authors report that continuous G-CSF application can elevate the blood neutrophils to such a level that the risk of infections is significantly reduced. Although the characteristic cycles are not eliminated by G-CSF, the period of the oscillations is shortened to 12-14 d. Based on a previously proposed computer-simulation model of human CN, the effects of continuous G-CSF application on CN are studied. It is shown how the known different cell-kinetic effects of G-CSF on granulopoiesis explain the clinical data in CN. The reduced length of the cycles emerges as a result of the transit time reduction of the post-mitotic granulopoietic cells by G-CSF. The measured increase of the neutrophil maxima is reproduced by the additional mitoses of the immature granulopoietic bone marrow cells induced by G-CSF. The slight elevation of the neutrophil nadirs can be attributed to a weak effect of G-CSF on the assumed underlying defect in CN (an abnormally small variance of the granulopoietic bone-marrow transit time).}, added-at = {2014-10-10T19:55:57.000+0200}, author = {Schmitz, S. and Franke, H. and Wichmann, Heinz-Erich and Diehl, Volker}, biburl = {https://www.bibsonomy.org/bibtex/2c2b0ee68db50b92d2ab5f289fc51aead/drtester}, interhash = {f69a61778831739197d8bf2cc9e8ac2c}, intrahash = {c2b0ee68db50b92d2ab5f289fc51aead}, journal = {British journal of haematology}, keywords = {IMISE-Publikationen}, number = 1, pages = {41–47}, timestamp = {2014-12-03T00:00:21.000+0100}, title = {The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis}, volume = 90, year = 1995 }