Induced haemodynamic and blood oxygenation changes occurring within
the brain of a ventilated newborn infant have been imaged in three
dimensions using optical tomography. Noninvasive measurements of
the flight times of transmitted light were acquired during illumination
of the brain by laser pulses at wavelengths of 780 nm and 815 nm.
The oxygen and carbon dioxide partial pressures were adjusted through
alterations to the ventilator settings, resulting in changes to the
cerebral blood volume and oxygenation. Three-dimensional images were
generated using the physiologically associated differences in the
measured data, obviating the need for data calibration using a separate
reference measurement. The results exhibit large changes in absorption
coefficient at both wavelengths. Images corresponding to differences
in concentrations of oxy- and deoxyhaemoglobin are in qualitative
agreement with known physiological data.
%0 Journal Article
%1 Hebden2004
%A Hebden, Jeremy C.
%A Gibson, Adam
%A Rozarina, Topun Austin
%A Everdell, Yusof Nick
%A Delpy, David T.
%A Arridge, Simon R.
%A Meek, Judith H.
%A Wyatt, John S.
%B Physics in Medicine and Biology
%D 2004
%K 2009 mps mps2009
%P --
%T Imaging changes in blood volume and oxygenation in the newborn infant
brain using three-dimensional optical tomography
%V 49
%X Induced haemodynamic and blood oxygenation changes occurring within
the brain of a ventilated newborn infant have been imaged in three
dimensions using optical tomography. Noninvasive measurements of
the flight times of transmitted light were acquired during illumination
of the brain by laser pulses at wavelengths of 780 nm and 815 nm.
The oxygen and carbon dioxide partial pressures were adjusted through
alterations to the ventilator settings, resulting in changes to the
cerebral blood volume and oxygenation. Three-dimensional images were
generated using the physiologically associated differences in the
measured data, obviating the need for data calibration using a separate
reference measurement. The results exhibit large changes in absorption
coefficient at both wavelengths. Images corresponding to differences
in concentrations of oxy- and deoxyhaemoglobin are in qualitative
agreement with known physiological data.
@article{Hebden2004,
abstract = {Induced haemodynamic and blood oxygenation changes occurring within
the brain of a ventilated newborn infant have been imaged in three
dimensions using optical tomography. Noninvasive measurements of
the flight times of transmitted light were acquired during illumination
of the brain by laser pulses at wavelengths of 780 nm and 815 nm.
The oxygen and carbon dioxide partial pressures were adjusted through
alterations to the ventilator settings, resulting in changes to the
cerebral blood volume and oxygenation. Three-dimensional images were
generated using the physiologically associated differences in the
measured data, obviating the need for data calibration using a separate
reference measurement. The results exhibit large changes in absorption
coefficient at both wavelengths. Images corresponding to differences
in concentrations of oxy- and deoxyhaemoglobin are in qualitative
agreement with known physiological data.},
added-at = {2009-11-19T14:40:48.000+0100},
author = {Hebden, Jeremy C. and Gibson, Adam and Rozarina, Topun Austin and Everdell, Yusof Nick and Delpy, David T. and Arridge, Simon R. and Meek, Judith H. and Wyatt, John S.},
biburl = {https://www.bibsonomy.org/bibtex/202626d4214713daa2084e64c82577d36/photonics},
booktitle = {Physics in Medicine and Biology},
interhash = {2a48442c382421df5fa05a48e2b63ec7},
intrahash = {02626d4214713daa2084e64c82577d36},
keywords = {2009 mps mps2009},
owner = {gianluca},
pages = {--},
refid = {479},
timestamp = {2009-11-19T14:40:56.000+0100},
title = {Imaging changes in blood volume and oxygenation in the newborn infant
brain using three-dimensional optical tomography},
volume = 49,
year = 2004
}