%0 Journal Article %1 guegan_apoptotic_1996 %A Guégan, C %A Boutin, H %A Boudry, C %A MacKenzie, E T %A Sola, B %D 1996 %J Comptes Rendus De l'Académie Des Sciences. Série III, Sciences De La Vie %K imported %N 10 %P 879--885 %T Apoptotic death in cortical neurons of mice subjected to focal ischemia %U http://www.ncbi.nlm.nih.gov/pubmed/8977768 %V 319 %X Permanent focal cortical ischemia was induced in mice by electrocoagulation of the middle cerebral artery. At different time intervals after the injury, the volume of infarction was assessed together with an analysis of neuronal death. Morphological studies of ischemic brains and detection of nucleosomal DNA ladder within ipsilateral cortices might implicate a component of this neuronal loss to apoptosis as well as necrosis. Furthermore, we used the TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling) procedure to detect in situ DNA fragmentation. The localization and the proportion of apoptotic cells in the ischemic mouse brain would indicate that apoptosis contributes largely to the cellular loss induced by cerebral ischemia.

@article{guegan_apoptotic_1996, abstract = {Permanent focal cortical ischemia was induced in mice by electrocoagulation of the middle cerebral artery. At different time intervals after the injury, the volume of infarction was assessed together with an analysis of neuronal death. Morphological studies of ischemic brains and detection of nucleosomal {DNA} ladder within ipsilateral cortices might implicate a component of this neuronal loss to apoptosis as well as necrosis. Furthermore, we used the {TUNEL} (terminal deoxynucleotidyl transferase-mediated {dUTP-biotin} nick end labelling) procedure to detect in situ {DNA} fragmentation. The localization and the proportion of apoptotic cells in the ischemic mouse brain would indicate that apoptosis contributes largely to the cellular loss induced by cerebral ischemia.}, added-at = {2011-03-24T16:45:37.000+0100}, author = {Guégan, C and Boutin, H and Boudry, C and {MacKenzie}, E T and Sola, B}, biburl = {https://www.bibsonomy.org/bibtex/23ead7068c2e3b0073904135469d44888/boudry}, interhash = {20bb813d0ea6fb213166e6318cc33d0e}, intrahash = {3ead7068c2e3b0073904135469d44888}, issn = {0764-4469}, journal = {Comptes Rendus De {l'Académie} Des Sciences. Série {III,} Sciences De La Vie}, keywords = {imported}, month = oct, note = {{PMID:} 8977768}, number = 10, pages = {879--885}, timestamp = {2011-03-24T16:45:37.000+0100}, title = {Apoptotic death in cortical neurons of mice subjected to focal ischemia}, url = {http://www.ncbi.nlm.nih.gov/pubmed/8977768}, volume = 319, year = 1996 }