The guinea-pig ventricular cell model, originally developed by Noble
et al in 1991, has been greatly extended to include accumulation
and depletion of calcium in a diadic space between the sarcolemma
and the sarcoplasmic reticulum where, according to contempory understanding,
the majority of calcium-induced calcium release is triggered. The
calcium in this space is also assumed to play the major role in calcium-induced
inactivation of the calcium current. Delayed potassium current equations
have been developed to include the rapid (IKr) and slow (IKs) components
of the delayed rectifier current based on the data of of Heath and
Terrar, along with data from Sanguinetti and Jurkiewicz. Length-
and tension-dependent changes in mechanical and electrophysiological
processes have been incorporated as described recently by Kohl et
al. Drug receptor interactions have started to be developed, using
the sodium channel as the first target. The new model has been tested
against experimental data on action potential clamp, and on force-interval
and duration-interval relations; it has been found to reliably reproduce
experimental observations.
%0 Journal Article
%1 Nobl_1998_123
%A Noble, D.
%A Varghese, A.
%A Kohl, P.
%A Noble, P.
%D 1998
%J Can. J. Cardiol.
%K 9487284 Animals, Cardiovascular, Channels, Computer Function, Guinea Heart Mathematics, Models, Pigs, Potassium Simulation, Sodium Theoretical, Ventricles, Ventricular
%N 1
%P 123--134
%T Improved guinea-pig ventricular cell model incorporating a diadic
space, IKr and IKs, and length- and tension-dependent processes.
%V 14
%X The guinea-pig ventricular cell model, originally developed by Noble
et al in 1991, has been greatly extended to include accumulation
and depletion of calcium in a diadic space between the sarcolemma
and the sarcoplasmic reticulum where, according to contempory understanding,
the majority of calcium-induced calcium release is triggered. The
calcium in this space is also assumed to play the major role in calcium-induced
inactivation of the calcium current. Delayed potassium current equations
have been developed to include the rapid (IKr) and slow (IKs) components
of the delayed rectifier current based on the data of of Heath and
Terrar, along with data from Sanguinetti and Jurkiewicz. Length-
and tension-dependent changes in mechanical and electrophysiological
processes have been incorporated as described recently by Kohl et
al. Drug receptor interactions have started to be developed, using
the sodium channel as the first target. The new model has been tested
against experimental data on action potential clamp, and on force-interval
and duration-interval relations; it has been found to reliably reproduce
experimental observations.
@article{Nobl_1998_123,
abstract = {The guinea-pig ventricular cell model, originally developed by Noble
et al in 1991, has been greatly extended to include accumulation
and depletion of calcium in a diadic space between the sarcolemma
and the sarcoplasmic reticulum where, according to contempory understanding,
the majority of calcium-induced calcium release is triggered. The
calcium in this space is also assumed to play the major role in calcium-induced
inactivation of the calcium current. Delayed potassium current equations
have been developed to include the rapid (IKr) and slow (IKs) components
of the delayed rectifier current based on the data of of Heath and
Terrar, along with data from Sanguinetti and Jurkiewicz. Length-
and tension-dependent changes in mechanical and electrophysiological
processes have been incorporated as described recently by Kohl et
al. Drug receptor interactions have started to be developed, using
the sodium channel as the first target. The new model has been tested
against experimental data on action potential clamp, and on force-interval
and duration-interval relations; it has been found to reliably reproduce
experimental observations.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Noble, D. and Varghese, A. and Kohl, P. and Noble, P.},
biburl = {https://www.bibsonomy.org/bibtex/20f17f51d91ef7a01a430db906611cd35/hake},
description = {The whole bibliography file I use.},
file = {Nobl_1998_123.pdf:Nobl_1998_123.pdf:PDF},
interhash = {48b1726ed99422a2b64cef5940bc595c},
intrahash = {0f17f51d91ef7a01a430db906611cd35},
journal = {Can. J. Cardiol.},
keywords = {9487284 Animals, Cardiovascular, Channels, Computer Function, Guinea Heart Mathematics, Models, Pigs, Potassium Simulation, Sodium Theoretical, Ventricles, Ventricular},
month = Jan,
number = 1,
pages = {123--134},
pmid = {9487284},
timestamp = {2009-06-03T11:21:24.000+0200},
title = {Improved guinea-pig ventricular cell model incorporating a diadic
space, IKr and IKs, and length- and tension-dependent processes.},
volume = 14,
year = 1998
}