%0 Journal Article %1 Keiz_1998_595 %A Keizer, J. %A Smith, G. D. %A Ponce-Dawson, S. %A Pearson, J. E. %D 1998 %J Biophys. J. %K Animals; Biological; Calcium Calcium, Cell Channel, Computer Diffusion; Kinetics; Membrane, Models, Muscle, Myocardium, Receptor Release Ryanodine Simulation; Skeletal, metabolism metabolism; %N 2 %P 595--600 %T Saltatory propagation of Ca$^2+$ waves by Ca$^2+$ sparks. %V 75 %X Punctate releases of Ca$^2+$, called Ca$^2+$ sparks, originate at the regular array of t-tubules in cardiac myocytes and skeletal muscle. During Ca$^2+$ overload sparks serve as sites for the initiation and propagation of Ca$^2+$ waves in myocytes. Computer simulations of spark-mediated waves are performed with model release sites that reproduce the adaptive Ca$^2+$ release observed for the ryanodine receptor. The speed of these waves is proportional to the diffusion constant of Ca$^2+$, D, rather than D, as is true for reaction-diffusion equations in a continuous excitable medium. A simplified "fire-diffuse-fire" model that mimics the properties of Ca$^2+$-induced Ca$^2+$ release (CICR) from isolated sites is used to explain this saltatory mode of wave propagation. Saltatory and continuous wave propagation can be differentiated by the temperature and Ca$^2+$ buffer dependence of wave speed.

@article{Keiz_1998_595, abstract = {Punctate releases of {C}a$^{2+}$, called {C}a$^{2+}$ sparks, originate at the regular array of t-tubules in cardiac myocytes and skeletal muscle. During {C}a$^{2+}$ overload sparks serve as sites for the initiation and propagation of {C}a$^{2+}$ waves in myocytes. Computer simulations of spark-mediated waves are performed with model release sites that reproduce the adaptive {C}a$^{2+}$ release observed for the ryanodine receptor. The speed of these waves is proportional to the diffusion constant of {C}a$^{2+}$, D, rather than D, as is true for reaction-diffusion equations in a continuous excitable medium. A simplified "fire-diffuse-fire" model that mimics the properties of {C}a$^{2+}$-induced {C}a$^{2+}$ release (CICR) from isolated sites is used to explain this saltatory mode of wave propagation. Saltatory and continuous wave propagation can be differentiated by the temperature and {C}a$^{2+}$ buffer dependence of wave speed.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Keizer, J. and Smith, G. D. and Ponce-Dawson, S. and Pearson, J. E.}, biburl = {https://www.bibsonomy.org/bibtex/2b8e8b74e3f9a96da14c00a8022f9163d/hake}, description = {The whole bibliography file I use.}, file = {Keiz_1998_595.pdf:Keiz_1998_595.pdf:PDF}, institution = {Institute of Theoretical Dynamics and Section on Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616 USA. jkeizer@ucdavis.edu}, interhash = {2153f975f9fb20f3389318bc13e387f1}, intrahash = {b8e8b74e3f9a96da14c00a8022f9163d}, journal = {Biophys. J.}, keywords = {Animals; Biological; Calcium Calcium, Cell Channel, Computer Diffusion; Kinetics; Membrane, Models, Muscle, Myocardium, Receptor Release Ryanodine Simulation; Skeletal, metabolism metabolism;}, month = Aug, number = 2, pages = {595--600}, pdf = {Keiz_1998_595.pdf}, pmid = {9675162}, timestamp = {2009-06-03T11:21:18.000+0200}, title = {Saltatory propagation of {C}a$^{2+}$ waves by {C}a$^{2+}$ sparks.}, volume = 75, year = 1998 }