The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3\%): 3 (7\%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2\%) of the patients with N. meningitidis serogroup A disease, and 2 (33\%) of the patients with infections due to uncommon serogroups and nongroupable strains of N. meningitidis. Of 91 additional patients with meningococcal infections due to uncommon serogroups, 33\% also had complement deficiency. Thirty-four of the 36 complement-deficient patients with meningococcal disease who were from 33 families were 5 years of age or older. Twenty-six additional complement-deficient relatives were found. Screening individuals with meningococcal disease due to uncommon serogroups who were 5 years of age or older identified 30 of the 33 complement-deficient families. Only 27\% of the complement-deficient relatives had had meningococcal disease. This risk was lower for relatives with properdin deficiency (18\%) than for those deficient in the late component of complement (38\%). Therefore, pedigree studies are warranted for identifying those complement-deficient persons who require vaccination for meningococcal disease.
%0 Journal Article
%1 fijen_assessment_1999
%A Fijen, C A
%A Kuijper, E J
%A te Bulte, M T
%A Daha, M R
%A Dankert, J
%D 1999
%J Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
%K Adolescent, Adult, Age Aged, Cerebrospinal Child, Complement Distribution, Fluid, Humans, Infant, Infections, Meningococcal Middle Neisseria Netherlands, Newborn, Pedigree, Preschool, Properdin, Proteins, Recurrence System meningitidis,
%N 1
%P 98--105
%R 10.1086/515075
%T Assessment of complement deficiency in patients with meningococcal disease in The Netherlands
%U http://www.ncbi.nlm.nih.gov/pubmed/10028078
%V 28
%X The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3\%): 3 (7\%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2\%) of the patients with N. meningitidis serogroup A disease, and 2 (33\%) of the patients with infections due to uncommon serogroups and nongroupable strains of N. meningitidis. Of 91 additional patients with meningococcal infections due to uncommon serogroups, 33\% also had complement deficiency. Thirty-four of the 36 complement-deficient patients with meningococcal disease who were from 33 families were 5 years of age or older. Twenty-six additional complement-deficient relatives were found. Screening individuals with meningococcal disease due to uncommon serogroups who were 5 years of age or older identified 30 of the 33 complement-deficient families. Only 27\% of the complement-deficient relatives had had meningococcal disease. This risk was lower for relatives with properdin deficiency (18\%) than for those deficient in the late component of complement (38\%). Therefore, pedigree studies are warranted for identifying those complement-deficient persons who require vaccination for meningococcal disease.
@article{fijen_assessment_1999,
abstract = {The frequency of complement deficiency in 176 of 7,732 patients with meningococcal disease in the Netherlands from 1959 through 1992 was assessed. Complement deficiency was found in six patients (3\%): 3 (7\%) of the patients with Neisseria meningitidis serogroup C disease, 1 (2\%) of the patients with N. meningitidis serogroup A disease, and 2 (33\%) of the patients with infections due to uncommon serogroups and nongroupable strains of N. meningitidis. Of 91 additional patients with meningococcal infections due to uncommon serogroups, 33\% also had complement deficiency. Thirty-four of the 36 complement-deficient patients with meningococcal disease who were from 33 families were 5 years of age or older. Twenty-six additional complement-deficient relatives were found. Screening individuals with meningococcal disease due to uncommon serogroups who were 5 years of age or older identified 30 of the 33 complement-deficient families. Only 27\% of the complement-deficient relatives had had meningococcal disease. This risk was lower for relatives with properdin deficiency (18\%) than for those deficient in the late component of complement (38\%). Therefore, pedigree studies are warranted for identifying those complement-deficient persons who require vaccination for meningococcal disease.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Fijen, C A and Kuijper, E J and te Bulte, M T and Daha, M R and Dankert, J},
biburl = {https://www.bibsonomy.org/bibtex/21b4b190cf27da1659c9a9d4e18690a68/jelias},
doi = {10.1086/515075},
interhash = {69c19b71311b6d2340cf27cd7980ea75},
intrahash = {1b4b190cf27da1659c9a9d4e18690a68},
issn = {1058-4838},
journal = {Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
keywords = {Adolescent, Adult, Age Aged, Cerebrospinal Child, Complement Distribution, Fluid, Humans, Infant, Infections, Meningococcal Middle Neisseria Netherlands, Newborn, Pedigree, Preschool, Properdin, Proteins, Recurrence System meningitidis,},
month = jan,
note = {{PMID:} 10028078},
number = 1,
pages = {98--105},
timestamp = {2011-03-11T10:05:40.000+0100},
title = {Assessment of complement deficiency in patients with meningococcal disease in The Netherlands},
url = {http://www.ncbi.nlm.nih.gov/pubmed/10028078},
volume = 28,
year = 1999
}