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Sarcoplasmic reticulum Ca$^2+$ refilling controls recovery from Ca$^2+$-induced Ca$^2+$ release refractoriness in heart muscle.

, , , , and . Circ. Res., 95 (8): 807--813 (October 2004)
DOI: 10.1161/01.RES.0000146029.80463.7d

Abstract

In cardiac muscle Ca$^2+$-induced Ca$^2+$ release (CICR) from the sarcoplasmic reticulum (SR) is initiated by Ca$^2+$ influx via L-type Ca$^2+$ channels. At present, the mechanisms underlying termination of SR Ca$^2+$ release, which are required to ensure stable excitation-contraction coupling cycles, are not precisely known. However, the same mechanism leading to refractoriness of SR Ca$^2+$ release could also be responsible for the termination of CICR. To examine the refractoriness of SR Ca$^2+$ release, we analyzed Na$^+$-Ca$^2+$ exchange currents reflecting cytosolic Ca$^2+$ signals induced by UV-laser flash-photolysis of caged …(more)

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