We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEMfor plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.
%0 Book Section
%1 frotscher2013simulation
%A Frotscher, Ralf
%A Goßmann, Matthias
%A Raatschen, Hans-Jürgen
%A Temiz-Artmann, Ayşegül
%A Staat, Manfred
%B Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures
%C Cham, Heidelberg
%D 2015
%E Altenbach, Holm
%E Mikhasev, Gennadi I.
%I Springer
%K imported
%P 187--212
%R 10.1007/978-3-319-02535-3_11
%T Simulation of Cardiac Cell-Seeded Membranes Using the Edge-Based Smoothed FEM
%U http://link.springer.com/chapter/10.1007/978-3-319-02535-3\_11 http://link.springer.com/10.1007/978-3-319-02535-3\_11
%V 45
%X We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEMfor plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.
%& 11
%@ 978-3-319-02534-6
@incollection{frotscher2013simulation,
abstract = {We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEMfor plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.},
added-at = {2019-12-23T09:34:32.000+0100},
address = {Cham, Heidelberg},
author = {Frotscher, Ralf and Go{\ss}mann, Matthias and Raatschen, Hans-J{\"{u}}rgen and Temiz-Artmann, Ayşeg{\"{u}}l and Staat, Manfred},
biburl = {https://www.bibsonomy.org/bibtex/230f2ff28d2f4fe9f026157ae21db6c35/staat},
booktitle = {Shell and Membrane Theories in Mechanics and Biology: From Macro- to Nanoscale Structures},
chapter = 11,
doi = {10.1007/978-3-319-02535-3_11},
editor = {Altenbach, Holm and Mikhasev, Gennadi I.},
interhash = {4286a35e2898c1f09dd42eae3e76286e},
intrahash = {30f2ff28d2f4fe9f026157ae21db6c35},
isbn = {978-3-319-02534-6},
keywords = {imported},
organization = {Минск: Изд. центр БГУ},
pages = {187--212},
publisher = {Springer},
series = {Advanced Structured Materials},
timestamp = {2019-12-23T09:34:32.000+0100},
title = {{Simulation of Cardiac Cell-Seeded Membranes Using the Edge-Based Smoothed FEM}},
url = {http://link.springer.com/chapter/10.1007/978-3-319-02535-3{\_}11 http://link.springer.com/10.1007/978-3-319-02535-3{\_}11},
volume = 45,
year = 2015
}