The enzyme monoamine oxidase A (MAO A) plays an important role in the metabolism of neurotransmitters. The MAOA gene presents several polymorphisms, including a 30-bp VNTR in the promoter region (MAOA-uVNTR). Alleles with 3.5 and 4 repeats are 2-10 times more efficient than the 3-repeat allele. Several studies have shown an association between the 3-repeat allele and a cluster of externalizing behaviors including alcoholism, antisocial personality, and impulsivity. The objective of the present study is to replicate in a different culture the associations between the MAOA-uVNTR with alcoholism and other phenotypes. The sample comprises 125 Brazilian alcoholics of European descent and 235 controls. The results suggest that the 3-repeat allele is associated to: (1) alcohol dependence (P<0.05); (2) an earlier onset of alcoholism (P<0.01); (3) comorbid drug abuse among alcoholics (P<0.05); and (4) a higher number of antisocial symptoms (P<0.02). Our results confirmed previous reports showing an association of the low activity 3-repeat allele of MAOA-uVNTR polymorphism with substance dependence and impulsive/antisocial behaviors. These findings in a different culture further support the influence of the MAOA-uVNTR in psychiatric disorders. (c) 2006 Wiley-Liss, Inc
%0 Book
%1 contin_maoa-uvntr_200
%A Contin, Veronica
%A Marque, Francine Z.C.
%A Garci, Carlos E.D.
%A Hut, Mara H.
%A Ba, Claiton H.D.
%D 200
%K alcohol-dependency biochemistry enzyme genetics maoa polymorphism
%P 305--30
%T MAOA-uVNTR polymorphism in a Brazilian sample: Further support for the association with impulsive behaviors and alcohol dependency
%U http://dx.doi.org/10.1002/ajmg.b.3029
%V 141
%X The enzyme monoamine oxidase A (MAO A) plays an important role in the metabolism of neurotransmitters. The MAOA gene presents several polymorphisms, including a 30-bp VNTR in the promoter region (MAOA-uVNTR). Alleles with 3.5 and 4 repeats are 2-10 times more efficient than the 3-repeat allele. Several studies have shown an association between the 3-repeat allele and a cluster of externalizing behaviors including alcoholism, antisocial personality, and impulsivity. The objective of the present study is to replicate in a different culture the associations between the MAOA-uVNTR with alcoholism and other phenotypes. The sample comprises 125 Brazilian alcoholics of European descent and 235 controls. The results suggest that the 3-repeat allele is associated to: (1) alcohol dependence (P<0.05); (2) an earlier onset of alcoholism (P<0.01); (3) comorbid drug abuse among alcoholics (P<0.05); and (4) a higher number of antisocial symptoms (P<0.02). Our results confirmed previous reports showing an association of the low activity 3-repeat allele of MAOA-uVNTR polymorphism with substance dependence and impulsive/antisocial behaviors. These findings in a different culture further support the influence of the MAOA-uVNTR in psychiatric disorders. (c) 2006 Wiley-Liss, Inc
%@ 1552-485
@book{contin_maoa-uvntr_200,
abstract = {The enzyme monoamine oxidase A {(MAO} A) plays an important role in the metabolism of neurotransmitters. The {MAOA} gene presents several polymorphisms, including a 30-bp {VNTR} in the promoter region {(MAOA-uVNTR).} Alleles with 3.5 and 4 repeats are 2-10 times more efficient than the 3-repeat allele. Several studies have shown an association between the 3-repeat allele and a cluster of externalizing behaviors including alcoholism, antisocial personality, and impulsivity. The objective of the present study is to replicate in a different culture the associations between the {MAOA-uVNTR} with alcoholism and other phenotypes. The sample comprises 125 Brazilian alcoholics of European descent and 235 controls. The results suggest that the 3-repeat allele is associated to: (1) alcohol dependence {(P<0.05);} (2) an earlier onset of alcoholism {(P<0.01);} (3) comorbid drug abuse among alcoholics {(P<0.05);} and (4) a higher number of antisocial symptoms {(P<0.02).} Our results confirmed previous reports showing an association of the low activity 3-repeat allele of {MAOA-uVNTR} polymorphism with substance dependence and impulsive/antisocial behaviors. These findings in a different culture further support the influence of the {MAOA-uVNTR} in psychiatric disorders. (c) 2006 {Wiley-Liss,} Inc},
added-at = {2009-11-04T09:54:44.000+0100},
author = {Contin, Veronica and Marque, Francine {Z.C.} and Garci, Carlos {E.D.} and Hut, Mara H. and Ba, Claiton {H.D.}},
biburl = {https://www.bibsonomy.org/bibtex/2334b0a3e2d5fd6b226dd028763f35a3f/rwst},
interhash = {63d5317d869301792b2a860405c6c699},
intrahash = {334b0a3e2d5fd6b226dd028763f35a3f},
isbn = {1552-485},
keywords = {alcohol-dependency biochemistry enzyme genetics maoa polymorphism},
pages = {305--30},
timestamp = {2009-11-04T09:54:44.000+0100},
title = {{MAOA-uVNTR} polymorphism in a Brazilian sample: Further support for the association with impulsive behaviors and alcohol dependency},
url = {http://dx.doi.org/10.1002/ajmg.b.3029},
volume = 141,
year = 200
}