Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds
M. Sharma. INTERNATIONAL JOURNAL OF TREND IN SCIENTIFIC RESEARCH AND DEVELOPMENT, 6 (5):
1653-1657(August 2022)
Abstract
The reaction of phenyl hydrazine with ethyl acetoacetate gave 3 methyl 1 phenyl 5 pyrazolone 1 , which then treated with malonitrile and benzaldehyde to give 6 amino 3 methyl 1,4 dihydropyrano 2,3 b pyrazole 5 carbonitrile 2 which considered assynthone for prepare some new pyrazole derivatives 3a j .The structure of the prepared compounds was suggested in the IR , 1 H NMR, 13 C NMR and UV Spectroscopy. Many steps starting from esterification of isophthalic acid to yield diester compound I which was converted to their acid hydrazide II , then the later compound reacted with ethylacetoacetate to yield pyrazol 5 one compound III . Afterword added acetyl chloride to give the compound IV , there action of this compound with theiosemicarbazide ledto produce a new carbothioamide compound V , Which was reacted with ethyl chloro acetate to yield thethioxoimidazolidin compound VI . The condensation reaction of this compound with different substituted aldehyde give new alkene derivatives VII a d. The synthesized compounds were characterized by melting points , FT IR ,1H NMR and Mass spectroscopy. Munesh Sharma "Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd51723.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/51723/synthesis-and-characterization-of-some-pyrazole-based-heterocyclic-compounds/munesh-sharma
%0 Journal Article
%1 noauthororeditor
%A Sharma, Munesh
%D 2022
%J INTERNATIONAL JOURNAL OF TREND IN SCIENTIFIC RESEARCH AND DEVELOPMENT
%K characterization compounds heterocyclic melting points pyrazole spectroscopy synthesis
%N 5
%P 1653-1657
%T Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds
%U https://www.ijtsrd.com/chemistry/other/51723/synthesis-and-characterization-of-some-pyrazole-based-heterocyclic-compounds/munesh-sharma
%V 6
%X The reaction of phenyl hydrazine with ethyl acetoacetate gave 3 methyl 1 phenyl 5 pyrazolone 1 , which then treated with malonitrile and benzaldehyde to give 6 amino 3 methyl 1,4 dihydropyrano 2,3 b pyrazole 5 carbonitrile 2 which considered assynthone for prepare some new pyrazole derivatives 3a j .The structure of the prepared compounds was suggested in the IR , 1 H NMR, 13 C NMR and UV Spectroscopy. Many steps starting from esterification of isophthalic acid to yield diester compound I which was converted to their acid hydrazide II , then the later compound reacted with ethylacetoacetate to yield pyrazol 5 one compound III . Afterword added acetyl chloride to give the compound IV , there action of this compound with theiosemicarbazide ledto produce a new carbothioamide compound V , Which was reacted with ethyl chloro acetate to yield thethioxoimidazolidin compound VI . The condensation reaction of this compound with different substituted aldehyde give new alkene derivatives VII a d. The synthesized compounds were characterized by melting points , FT IR ,1H NMR and Mass spectroscopy. Munesh Sharma "Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd51723.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/51723/synthesis-and-characterization-of-some-pyrazole-based-heterocyclic-compounds/munesh-sharma
@article{noauthororeditor,
abstract = {The reaction of phenyl hydrazine with ethyl acetoacetate gave 3 methyl 1 phenyl 5 pyrazolone 1 , which then treated with malonitrile and benzaldehyde to give 6 amino 3 methyl 1,4 dihydropyrano 2,3 b pyrazole 5 carbonitrile 2 which considered assynthone for prepare some new pyrazole derivatives 3a j .The structure of the prepared compounds was suggested in the IR , 1 H NMR, 13 C NMR and UV Spectroscopy. Many steps starting from esterification of isophthalic acid to yield diester compound I which was converted to their acid hydrazide II , then the later compound reacted with ethylacetoacetate to yield pyrazol 5 one compound III . Afterword added acetyl chloride to give the compound IV , there action of this compound with theiosemicarbazide ledto produce a new carbothioamide compound V , Which was reacted with ethyl chloro acetate to yield thethioxoimidazolidin compound VI . The condensation reaction of this compound with different substituted aldehyde give new alkene derivatives VII a d. The synthesized compounds were characterized by melting points , FT IR ,1H NMR and Mass spectroscopy. Munesh Sharma "Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd51723.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/51723/synthesis-and-characterization-of-some-pyrazole-based-heterocyclic-compounds/munesh-sharma
},
added-at = {2022-09-03T13:50:59.000+0200},
author = {Sharma, Munesh},
biburl = {https://www.bibsonomy.org/bibtex/23a08110a652e841562adcf2ff25317a0/ijtsrd},
interhash = {c9259e2c06e3c9915c509b6886d51be0},
intrahash = {3a08110a652e841562adcf2ff25317a0},
issn = {2456-6470},
journal = {INTERNATIONAL JOURNAL OF TREND IN SCIENTIFIC RESEARCH AND DEVELOPMENT},
keywords = {characterization compounds heterocyclic melting points pyrazole spectroscopy synthesis},
language = {english},
month = aug,
number = 5,
pages = {1653-1657},
timestamp = {2022-09-03T13:50:59.000+0200},
title = {Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds
},
url = {https://www.ijtsrd.com/chemistry/other/51723/synthesis-and-characterization-of-some-pyrazole-based-heterocyclic-compounds/munesh-sharma},
volume = 6,
year = 2022
}