Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
%0 Journal Article
%1 gayan2010genetic
%A Gayán, J
%A Galan, J J
%A González-Pérez, A
%A Sáez, M E
%A Martínez-Larrad, M T
%A Zabena, C
%A Rivero, M C
%A Salinas, A
%A Ramírez-Lorca, R
%A Morón, F J
%A Royo, J L
%A Moreno-Rey, C
%A Velasco, J
%A Carrasco, J M
%A Molero, E
%A Ochoa, C
%A Ochoa, M D
%A Gutiérrez, M
%A Reina, M
%A Pascual, R
%A Romo-Astorga, A
%A Susillo-González, J L
%A Vázquez, E
%A Real, L M
%A Ruiz, A
%A Serrano-Ríos, M
%D 2010
%J BMC Genomics
%K eurogenetics iberian_peninsula linkage
%P 326-326
%R 10.1186/1471-2164-11-326
%T Genetic structure of the Spanish population
%U http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887418/
%V 11
%X Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.
@article{gayan2010genetic,
abstract = {Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.},
added-at = {2012-04-23T03:10:58.000+0200},
author = {Gay{\'a}n, J and Galan, J J and Gonz{\'a}lez-P{\'e}rez, A and S{\'a}ez, M E and Mart{\'i}nez-Larrad, M T and Zabena, C and Rivero, M C and Salinas, A and Ram{\'i}rez-Lorca, R and Mor{\'o}n, F J and Royo, J L and Moreno-Rey, C and Velasco, J and Carrasco, J M and Molero, E and Ochoa, C and Ochoa, M D and Guti{\'e}rrez, M and Reina, M and Pascual, R and Romo-Astorga, A and Susillo-Gonz{\'a}lez, J L and V{\'a}zquez, E and Real, L M and Ruiz, A and Serrano-R{\'i}os, M},
biburl = {https://www.bibsonomy.org/bibtex/23a18b22a3e093aa9b64afe652dfb239b/peter.ralph},
description = {Genetic Structure of the Spanish Population},
doi = {10.1186/1471-2164-11-326},
interhash = {5bb2a1712a8013c5196c10282aa2ed6f},
intrahash = {3a18b22a3e093aa9b64afe652dfb239b},
journal = {BMC Genomics},
keywords = {eurogenetics iberian_peninsula linkage},
pages = {326-326},
pmid = {20500880},
timestamp = {2012-04-23T03:10:58.000+0200},
title = {Genetic structure of the {Spanish} population},
url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2887418/},
volume = 11,
year = 2010
}