Anticoagulant peptide fragments derived from apolipoprotein B-100
United States Patent, (декабря 1998)Аннотация
The present invention provides a peptide compound of formula Z.sup.1 --K--A--Q--X.sup.1 --K--K--N--K--H--R--H--S--X.sup.2 --T--Z.sup.2 (SEQ ID NO:1) where: X.sup.1 represents S or Y, X.sup.2 represents T or I, Z.sup.1 represents the N terminus of the peptide, or from 1 to 47 amino acids, Z.sup.2 represents the C terminus of the peptide, a terminal amide group, or from 1 to 77 amino acids; or a variant of this peptide which contains one or more internal deletions, insertions or substitutions and which substantially retains anti-coagulant properties of apoB-100.