%0 Journal Article %1 Albert:2007:Nat-Methods:17934467 %A Albert, T J %A Molla, M N %A Muzny, D M %A Nazareth, L %A Wheeler, D %A Song, X %A Richmond, T A %A Middle, C M %A Rodesch, M J %A Packard, C J %A Weinstock, G M %A Gibbs, R A %D 2007 %J Nat Methods %K SHOULDREAD enrichment exome sequencing wes %N 11 %P 903-905 %R 10.1038/nmeth1111 %T Direct selection of human genomic loci by microarray hybridization %U https://www.ncbi.nlm.nih.gov/pubmed/17934467 %V 4 %X We applied high-density microarrays to the enrichment of specific sequences from the human genome for high-throughput sequencing. After capture of 6,726 approximately 500-base 'exon' segments, and of 'locus-specific' regions ranging in size from 200 kb to 5 Mb, followed by sequencing on a 454 Life Sciences FLX sequencer, most sequence reads represented selection targets. These direct selection methods supersede multiplex PCR for the large-scale analysis of genomic regions.

@article{Albert:2007:Nat-Methods:17934467, abstract = {We applied high-density microarrays to the enrichment of specific sequences from the human genome for high-throughput sequencing. After capture of 6,726 approximately 500-base 'exon' segments, and of 'locus-specific' regions ranging in size from 200 kb to 5 Mb, followed by sequencing on a 454 Life Sciences FLX sequencer, most sequence reads represented selection targets. These direct selection methods supersede multiplex PCR for the large-scale analysis of genomic regions.}, added-at = {2017-10-24T23:02:30.000+0200}, author = {Albert, T J and Molla, M N and Muzny, D M and Nazareth, L and Wheeler, D and Song, X and Richmond, T A and Middle, C M and Rodesch, M J and Packard, C J and Weinstock, G M and Gibbs, R A}, biburl = {https://www.bibsonomy.org/bibtex/24371cb60010243774472c970ec5f7b79/marcsaric}, description = {Direct selection of human genomic loci by microarray hybridization. - PubMed - NCBI}, doi = {10.1038/nmeth1111}, interhash = {3838d43f6a2a163dc712aa407a454035}, intrahash = {4371cb60010243774472c970ec5f7b79}, journal = {Nat Methods}, keywords = {SHOULDREAD enrichment exome sequencing wes}, month = nov, number = 11, pages = {903-905}, pmid = {17934467}, timestamp = {2017-10-24T23:03:01.000+0200}, title = {Direct selection of human genomic loci by microarray hybridization}, url = {https://www.ncbi.nlm.nih.gov/pubmed/17934467}, volume = 4, year = 2007 }