A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-F-18fluoro-D-glucose in murine models of breast cancer.
We used small animal positron emission tomography (PET) imaging to monitor the time-course of tumor metabolic response to hormone and chemotherapy in a murine model of hormone-sensitive breast cancer.Estrogen receptor positive murine mammary carcinomas were inoculated in Balb/c mice. Small animal PET imaging using 2-deoxy-2-F-18fluoro-D: -glucose (FDG) was used to assess tumor metabolic activity. Imaging was done before and at days 1, 7, and 14 after the administration of doxorubicin, methotrexate, letrozole, or placebo. The tumor uptake of FDG was calculated from a region-of-interest drawn around the tumor.All treatments resulted in a decrease in tumor growth rate and end volume compared to untreated control. FDG uptake was also markedly decreased after treatment although a flare reaction was observed on PET at day 7, the intensity of which varied according to the treatment modality.PET imaging is sensitive to detect early changes associated with therapy in murine breast cancer models. A flare reaction was observed 7 days after the initiation of therapy.
Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
%0 Journal Article
%1 Aliaga2007
%A Aliaga, Antonio
%A Rousseau, Jacques A
%A Cadorette, Jules
%A Croteau, Etienne
%A van Lier, Johan E
%A Lecomte, Roger
%A Bénard, François
%D 2007
%J Mol Imaging Biol
%K drugtherapy/metabolism/radionuclideimaging;Nitriles therapeuticuse;rlecomte Estrogen diagnosticuse;MammaryNeoplasms Animals;AntineoplasticAgents therapeuticuse;BloodGlucose diagnosticuse;Receptors diagnosticuse;FluorodeoxyglucoseF18 therapeuticuse;Female;FluorineRadioisotopes InbredBALBC;Neoplasms metabolism;Doxorubicin drugtherapy/metabolism/radionuclideimaging;Methotrexate Hormone-Dependent therapeuticuse;Mice;Mice Experimental metabolism;Triazoles therapeuticuse;Positron-EmissionTomography methods;Radiopharmaceuticals
%N 3
%P 144--150
%R 10.1007/s11307-007-0091-6
%T A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-F-18fluoro-D-glucose in murine models of breast cancer.
%U http://dx.doi.org/10.1007/s11307-007-0091-6
%V 9
%X We used small animal positron emission tomography (PET) imaging to monitor the time-course of tumor metabolic response to hormone and chemotherapy in a murine model of hormone-sensitive breast cancer.Estrogen receptor positive murine mammary carcinomas were inoculated in Balb/c mice. Small animal PET imaging using 2-deoxy-2-F-18fluoro-D: -glucose (FDG) was used to assess tumor metabolic activity. Imaging was done before and at days 1, 7, and 14 after the administration of doxorubicin, methotrexate, letrozole, or placebo. The tumor uptake of FDG was calculated from a region-of-interest drawn around the tumor.All treatments resulted in a decrease in tumor growth rate and end volume compared to untreated control. FDG uptake was also markedly decreased after treatment although a flare reaction was observed on PET at day 7, the intensity of which varied according to the treatment modality.PET imaging is sensitive to detect early changes associated with therapy in murine breast cancer models. A flare reaction was observed 7 days after the initiation of therapy.
@article{Aliaga2007,
abstract = {We used small animal positron emission tomography (PET) imaging to monitor the time-course of tumor metabolic response to hormone and chemotherapy in a murine model of hormone-sensitive breast cancer.Estrogen receptor positive murine mammary carcinomas were inoculated in Balb/c mice. Small animal PET imaging using 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG) was used to assess tumor metabolic activity. Imaging was done before and at days 1, 7, and 14 after the administration of doxorubicin, methotrexate, letrozole, or placebo. The tumor uptake of FDG was calculated from a region-of-interest drawn around the tumor.All treatments resulted in a decrease in tumor growth rate and end volume compared to untreated control. FDG uptake was also markedly decreased after treatment although a flare reaction was observed on PET at day 7, the intensity of which varied according to the treatment modality.PET imaging is sensitive to detect early changes associated with therapy in murine breast cancer models. A flare reaction was observed 7 days after the initiation of therapy.},
added-at = {2011-07-21T21:30:46.000+0200},
author = {Aliaga, Antonio and Rousseau, Jacques A and Cadorette, Jules and Croteau, Etienne and van Lier, Johan E and Lecomte, Roger and Bénard, François},
biburl = {https://www.bibsonomy.org/bibtex/24443feaf09936b89f22695212a6e51af/crc_chus},
doi = {10.1007/s11307-007-0091-6},
institution = {Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.},
interhash = {283397e903d40b57ee59b533a5d79dd9},
intrahash = {4443feaf09936b89f22695212a6e51af},
journal = {Mol Imaging Biol},
keywords = {drugtherapy/metabolism/radionuclideimaging;Nitriles therapeuticuse;rlecomte Estrogen diagnosticuse;MammaryNeoplasms Animals;AntineoplasticAgents therapeuticuse;BloodGlucose diagnosticuse;Receptors diagnosticuse;FluorodeoxyglucoseF18 therapeuticuse;Female;FluorineRadioisotopes InbredBALBC;Neoplasms metabolism;Doxorubicin drugtherapy/metabolism/radionuclideimaging;Methotrexate Hormone-Dependent therapeuticuse;Mice;Mice Experimental metabolism;Triazoles therapeuticuse;Positron-EmissionTomography methods;Radiopharmaceuticals},
language = {eng},
medline-pst = {ppublish},
number = 3,
pages = {144--150},
pmid = {17334852},
timestamp = {2011-07-21T21:30:46.000+0200},
title = {A small animal positron emission tomography study of the effect of chemotherapy and hormonal therapy on the uptake of 2-deoxy-2-[F-18]fluoro-D-glucose in murine models of breast cancer.},
url = {http://dx.doi.org/10.1007/s11307-007-0091-6},
volume = 9,
year = 2007
}