%0 Journal Article %1 khaled_mohammad_juma_husain_bani_hani_2024_11363156 %A Hani, Khaled Mohammad Juma Husain Bani %A Alghamaz, Sinan Ibrahim %A Doumi, Madher Ali Mohammad %A Aldarawshe, Rami Mohamad Salem %A Dawaghreh, Suhib Fayiz Naim %A Alboun, Ahmed Mahmoud Mohammed Ali %A Quraan, Kholoud Muhsen Al %D 2024 %J World Journal of Biology Pharmacy and Health Sciences %K Bisphosphonate %N 3 %P 205–220 %R 10.30574/wjbphs.2024.17.3.0120 %T Optimal dual calcium and cholecalciderol dosages for osteoporotic fracture risk patients %U https://wjbphs.com/content/optimal-dual-calcium-and-cholecalciderol-dosages-osteoporotic-fracture-risk-patients %V 17 %X Background: Vitamin D is crucial for musculoskeletal health, promoting calcium absorption, osteoid tissue mineralization, and muscle function. Insufficient levels can lead to bone dystrophy, muscle weakness, and osteoporotic fractures. Aims: This research investigates the correlation between bone mineral density and osteoporotic fracture risk, including positive and negative influences, and aims to determine the optimal vitamin D level. Methods: This retrospective observational study examined 206 Jordanian rehabilitation and rheumatology clinic patients from September to November 2021. The participants were post-menopausal women and men over 60. The Age-adjusted Charlson Co-Morbidity Index and Functionality Grade system was used to assess participants' co-morbidity burden and functionality. DEXA scans assessed participants' proximal femoral hip and anteroposterior spine. Participants were divided into two Vit D groups: those below 30 ng/ml and those above 30. Results were compared using a Chi Square test. The study examined correlations, total variations, and Vit D prediction quality using logistic regression analyses. SPSS 23.0 was used for statistical analysis with a 5% significance level. Results: A binary logistic regression model was employed to simulate the correlation between the vitamin D levels of patients and their bone mineral density. The model indicated a 61.39% likelihood of having a fH_BMD (femoral head bone mineral density) equal to or greater than 0.755 g/cm2 when the vitamin D level is at its optimal value of 27.25 ng/ml. The model indicated a 27.25% likelihood of a fHOPF risk-free tool with a value of ≥3% when the optimal vitamin D level is 27.25 ng/ml. The model indicated a 17.74% likelihood of experiencing a significant osteoporotic fracture within the next 10 years. Conclusion: The findings of our study demonstrated a direct correlation between elevated levels of vitamin D and improved bone mineral quality indices that were examined. The serum 25-OH Cholecalciferol levels are more likely to have a beneficial effect on bone health status.

@article{khaled_mohammad_juma_husain_bani_hani_2024_11363156, abstract = {Background: Vitamin D is crucial for musculoskeletal health, promoting calcium absorption, osteoid tissue mineralization, and muscle function. Insufficient levels can lead to bone dystrophy, muscle weakness, and osteoporotic fractures. Aims: This research investigates the correlation between bone mineral density and osteoporotic fracture risk, including positive and negative influences, and aims to determine the optimal vitamin D level. Methods: This retrospective observational study examined 206 Jordanian rehabilitation and rheumatology clinic patients from September to November 2021. The participants were post-menopausal women and men over 60. The Age-adjusted Charlson Co-Morbidity Index and Functionality Grade system was used to assess participants' co-morbidity burden and functionality. DEXA scans assessed participants' proximal femoral hip and anteroposterior spine. Participants were divided into two Vit D groups: those below 30 ng/ml and those above 30. Results were compared using a Chi Square test. The study examined correlations, total variations, and Vit D prediction quality using logistic regression analyses. SPSS 23.0 was used for statistical analysis with a 5% significance level. Results: A binary logistic regression model was employed to simulate the correlation between the vitamin D levels of patients and their bone mineral density. The model indicated a 61.39% likelihood of having a fH_BMD (femoral head bone mineral density) equal to or greater than 0.755 g/cm2 when the vitamin D level is at its optimal value of 27.25 ng/ml. The model indicated a 27.25% likelihood of a fHOPF risk-free tool with a value of ≥3% when the optimal vitamin D level is 27.25 ng/ml. The model indicated a 17.74% likelihood of experiencing a significant osteoporotic fracture within the next 10 years. Conclusion: The findings of our study demonstrated a direct correlation between elevated levels of vitamin D and improved bone mineral quality indices that were examined. The serum 25-OH Cholecalciferol levels are more likely to have a beneficial effect on bone health status.}, added-at = {2024-06-07T05:51:05.000+0200}, author = {Hani, Khaled Mohammad Juma Husain Bani and Alghamaz, Sinan Ibrahim and Doumi, Madher Ali Mohammad and Aldarawshe, Rami Mohamad Salem and Dawaghreh, Suhib Fayiz Naim and Alboun, Ahmed Mahmoud Mohammed Ali and Quraan, Kholoud Muhsen Al}, biburl = {https://www.bibsonomy.org/bibtex/24475e1a960f130383c3497313200ac58/wjbphsjournal}, doi = {10.30574/wjbphs.2024.17.3.0120}, interhash = {3886ae3ff72e91d3b0dd6049f2121455}, intrahash = {4475e1a960f130383c3497313200ac58}, issn = {2582-5542}, journal = {{World Journal of Biology Pharmacy and Health Sciences}}, keywords = {Bisphosphonate}, month = may, number = 3, pages = {205–220}, timestamp = {2024-06-07T05:51:05.000+0200}, title = {Optimal dual calcium and cholecalciderol dosages for osteoporotic fracture risk patients}, url = {https://wjbphs.com/content/optimal-dual-calcium-and-cholecalciderol-dosages-osteoporotic-fracture-risk-patients}, volume = 17, year = 2024 }